LASV inhibitor 3.3|LAMP1 inhibitor 3.3|CAS 554438-52-7

Cas No.:	554438-52-7
Chemical Name:	N-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)adamantane-1-carboxamide
Synonyms:	LAMP1 inhibitor 3.3
SMILES:	C(C(NCC(N1CCN(C(C2=CC=CC=C2)C2=CC=CC=C2)CC1)=O)=O)12CC3CC(CC(C3)C1)C2
Formula:	C₃₀H₃₇N₃O₂
M.Wt:	471.645
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Wang MK, et al. PLoS Pathog. 2018 Sep 28;14(9):e1007322. 2. PCT Int. Appl. (2013), WO 2013022550 A2 20130214.

Description:

LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells; does not inhibits the GP-mediated infection of LCMV, LuJo virus (LUJV) or Junin virus (JUNV), Ebola virus (EBOV) or vesicular stomatitis virus (VSV); inhibits LAMP1 binding to LASV GP, which is cholesterol-dependent and sensitive to 3.3 inhibition; LASV inhibitor 3.3 is a competitive inhibitor of cholesterol binding to LAMP1.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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