Org 27569|cas 868273-06-7|DC Chemicals|Price|Buy

Cas No.:	868273-06-7
Chemical Name:	N-(4-(piperidin-1-yl)phenethyl)-5-chloro-3-ethyl-1H-indole-2-carboxamide
Synonyms:	Org-27569; Org27569
SMILES:	ClC1=CC=C(C2=C1)NC(C(NCCC3=CC=C(C=C3)N4CCCCC4)=O)=C2CC
Formula:	C₂₄H₂₈ClN₃O
M.Wt:	409.95
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist and causes a significant decrease in specific binding of CB1 receptor inverse agonist. Org 27569 induces CB1 high affinity agonist binding, receptor internalization, and downstream ERK phosphorylation. The allosteric ligand Org 27569 promotes agonist binding to CB1, yet blocks the agonist-induced con Formational changes in TM6. Org 27569 traps the receptor in a distinct agonist-bound, but nonsignaling con Formational state. For the detailed information of Org 27569, the solubility of Org 27569 in water, the solubility of Org 27569 in DMSO, the solubility of Org 27569 in PBS buffer, the animal experiment (test) of Org 27569, the cell expriment (test) of Org 27569, the in vivo, in vitro and clinical trial test of Org 27569, the EC50, IC50,and Affinity of Org 27569, Please contact DC Chemicals.

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2018-0101

Cat. No.	Product name	Field of application
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