Pamabrom|CAS 606-04-2|DC Chemicals

Cas No.:	606-04-2
Chemical Name:	Pamabrom
Synonyms:	Pamabrom;8-BROMOTHEOPHYLLINE COMPOUND WITH 2-AMINO-2-METHYL-1-PROPANOL (1:1);2-amino-2-methylpropanol 8-bromotheophyllinate;PAMABROM,USP;2-azanyl-2-methyl-propan-1-ol;8-bromo-1,3-dimethyl-7H-purine-2,6-dione;8-bromo-1,3-dimethyl-7H-purine-2,6-quinone;2-AMino-2-Methyl-1-propanol 8-broMotheophyllinate;2-amino-2-methylpropan-1-ol,8-bromo-1,3-dimethyl-7H-purine-2,6-dione;8-Brom-1,3-dimethyl-3,7-dihydro-purin-2,6-dion,Verbindung mit 2-Amino-2-methyl-propan-1-ol;8-bromo-1,3-dimethyl-3,7-dihydro-purine-2,6-dione,compound with 2-amino-2-methyl-propan-1-ol;8-bromo-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;Predema;Premsyn PMS;Sunril;UNII-UA8U0KJM72;8-Bromotheophylline 2-Amino-2-methyl-1-propanol;2-Amino-2-methylpropanol 8-bromotheophyllinate
SMILES:	OCC(N)(C)C.BrC1=NC2N(C(N(C(=O)C=2N1)C)=O)C
Formula:	C₁₁H₁₈BrN₅O₃
M.Wt:	348.19632101059
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms. The active diuretic ingredient in pamabrom is 8-bromotheophylline. Pamabrom is available in combination with acetaminophen (paracetamol) for various conditions such as back pain and menstrual relief. The acetaminophen helps reduce menstrual pains and the pamabrom reduces associated bloating.

References:

[1]. Ortiz MI, Rangel-Flores E, Carrillo-Alarcón LC, et al. Prevalence and impact of primary dysmenorrhea among Mexican high school students. Int J Gynaecol Obstet. 2009 Dec;107(3):240-3. [2]. Swanson JK, English JC 3rd. Serum sickness-like reaction to Pamabrom. J Drugs Dermatol. 2006 Mar;5(3):284-6. [3]. Di Girolamo G, Sánchez AJ, De Los Santos AR, et al. Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? Expert Opin Pharmacother. 2004 Mar;5(3):561-70. [4]. Pamabrom

MSDS

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MSDS_14377_DC32065_606-04-2

COA

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DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC74557	PREX-in1	PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
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DC74223	X-Neu5Ac	X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a Km of 0.89 mM for neuraminidase.
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
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