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Picrotin

  Cat. No.:  DC28212   Featured
Chemical Structure
21416-53-5
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More than 5000 active chemicals with high quality for research!
Field of application
Picrotin is an inhibitor of glycine receptors (GlyRs) which blocks α2 GlyR, α1 GlyR and α3 GlyR.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 21416-53-5
Chemical Name: 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione,hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-,(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-
Synonyms: 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione,hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-,(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-;PICROTIN;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione,hexahydro-2a-hydrox...;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione,hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8;PICROTIN(RG);(-)-Picrotin;(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione;picrotoxin component 2
SMILES: CC([C@@H]1[C@H]2OC(=O)[C@@H]1[C@@]1(C[C@H]3O[C@@]43C(O[C@H]2[C@]14C)=O)O)(C)O
Formula: C15H18O7
M.Wt: 310.299225330353
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Picrotin is an inhibitor of glycine receptors (GlyRs) which blocks α2 GlyR, α1 GlyR and α3 GlyR[1][2].
Target: α2 GlyR, α1 GlyR, α3 GlyR[1][2]
References: [1]. Li P, et al. Gating effects on picrotin block of glycine receptors. Neuroreport. 2012 Dec 5;23(17):1017-20. [2]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9.
MSDS
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MSDS_12267_DC28212_21416-53-5
COA
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