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Prednisolone phosphate sodium

  Cat. No.:  DC31819   Featured
Chemical Structure
125-02-0
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More than 5000 active chemicals with high quality for research!
Field of application
Prednisolone sodium phosphate is a water soluble form of prednisolone, a glucocorticoid. It is used to treat a variety of inflammatory and autoimmune conditions and some cancers. It is the active metabolite of the drug prednisone and is used especially in patients with liver failure, as these individuals are unable to metabolize prednisone into active prednisolone.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 125-02-0
Chemical Name: prednisolone 21-(disodium phosphate)
Synonyms: prednisolone 21-(disodium phosphate);Prednisolone Sodium Phosphate;Prednisoline 21-phosphonic acid disodium salt;Disodium Prednisolone 21-Phosphate;Prednisolone (disodium phosphate);Prednisolone 21-phosphate disodium;Prednisolone Phosphate (sodium salt);Prednisolone phosphate sodium;Sodiumprednisolone-21-phosphate;(11beta);Ak-pred;codelsol;Dojilon;inflamase;Metreton;optival;prednisolon disodium phosphate;prednisolone 21-disodium phosphate;Prednisolone 21-Phosphate Disodium Salt;predsol;prozorin;solucort;Prednisolone 21-phosphate disodium salt;(11b)-11,17-Dihydroxy-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione disodium salt;Disodium prednisolone 21-phosphate;(11beta)-
SMILES: [Na+].[Na+].O=P(OCC([C@]1(CC[C@H]2[C@@H]3CCC4=CC(C=C[C@]4(C)C3C(C[C@]12C)O)=O)O)=O)([O-])[O-]
Formula: C21H27Na2O8P
M.Wt: 484.387589693069
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].
Target: Glucocorticoid Receptor
References: [1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95. [2]. http://en.wikipedia.org/wiki/Prednisolone
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MSDS_14131_DC31819_125-02-0
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