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Home > Molecular Glues

SJ6986

  Cat. No.:  DC55050   Featured
Chemical Structure
2765625-93-0
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More than 5000 active chemicals with high quality for research!
Field of application
SJ6986 is a highly potent, selective, and orally bioavailable degrader of GSPT1/2, with a DC50 of 2.1 nM. It exhibits strong antiproliferative effects in MV4-11 and MHH-CALL-4 cell lines, showing IC50 values of 1.5 nM and 0.4 nM, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2765625-93-0
Chemical Name: SJ6986
Synonyms: SJ6986
SMILES: O=C1C2=CC(NS(C3C=CC=CC=3OC(F)(F)F)(=O)=O)=CC=C2C(=O)N1C1CCC(=O)NC1=O
Formula: C20H14F3N3O7S
M.Wt: 497.40
Purity: >97%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. J Med Chem. 2021 06 10; 64(11):7296-7311.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC67413 MRT-23227
DC67412 MRT-3486
DC67411 MRT-7612
DC67410 MRT-10350
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