Thalidomide|cas 50-35-1|DC Chemicals

Cas No.:	50-35-1
SMILES:	O=C1CCC(N2C(=O)C3=CC=CC=C3C2=O)C(=O)N1
Formula:	C₁₃H₁₀N₂O₄
M.Wt:	258.23
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.Thalidomide was commonly used therapeutically in the late 1950's; however, it was withdrawn from the market when it was discovered to cause birth defects. More recent research has found Thalidomide to affect key biochemical pathways yielding antiangiogenic and immunomodulatory activities. This compound has been shown to: selectively inhibit tumor necrosis factor-alpha (TNF alpha) biosynthesis and basic fibroblast growth factor (bFGF)-induced angiogenesis, induce apoptosis in human monocytes via a cytochrome c-dependent pathway, and to inhibit HIV-1 replication in a monocytoid (U1) line. These new found uses make Thalidomide an extremely valuable research tool.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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DC67412	MRT-3486
DC67411	MRT-7612
DC67410	MRT-10350
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