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FR901465

  Cat. No.:  DC45924   Featured
Chemical Structure
146478-73-1
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More than 5000 active chemicals with high quality for research!
Field of application
FR901465 is a potent anti-cancer and anti-tumor agent. FR901465 can be used for cancer research.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 146478-73-1
Chemical Name: 2-Pentenamide,4-(acetyloxy)-N-[(2R,3R,5S,6S)-tetrahydro-2,5-dimethyl-6-[(2E,4E)-3-methyl-5-[(3R,4R,5S,7R,8R)-4,5,8-trihydroxy-5-methyl-1,6-dioxaspiro[2.5]oct-7-yl]-2,4-pentadien-1-yl]-2H-pyran-3-yl]-,(2Z,4S)-
SMILES: CC(=O)O[C@@H](C)\C=C/C(=O)N[C@H]1[C@@H](C)O[C@@H](C\C=C(/C)\C=C\[C@@H]2[C@@H](O)[C@]3(OC3)[C@@H](O)[C@@](O)(C)O2)[C@@H](C)C1
Formula: C27H41NO9
M.Wt: 523.61574
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: FR901465 is a potent anti-cancer and anti-tumor agent. FR901465 can be used for cancer research[1].
In Vitro: FR901465 prolongs the life of mice bearing murine ascitic tumor P388 leukemia (T/C values 127% for FR901465 in mice bearing murine ascitic tumors[1].
References: [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11. [2]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465. J Antibiot (Tokyo). 1997 Jan;50(1):96-9. [3]. Ratnakar N. Asolkar, et al. Discovery and Development of Natural Products for Pest Management. RETURN TO BOOKPREVCHAPTERNEXT
MSDS
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MSDS_29717_DC45924_146478-73-1
COA
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Cat. No. Product name Field of application
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DC31074 Isopropyl myristate Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
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DC74576 Fluorofurimazine Fluorofurimazine is a novel furimazine analogue, with increased aqueous solubility enabling higher signal emission than furimazine for bioluminescence imaging. Fluorofurimazine enables higher substrate loading and improved optical imaging sensitivity in in-vivo.
DC74557 PREX-in1 PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555 GYS32661 GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539 L557-0155 L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
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