linderalactone

Cas No.:	728-61-0
Chemical Name:	Linderalactone
Synonyms:	Linderalactone;(4R,10E)-3,11-Dimethyl-4,8,9,12-tetrahydro-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one;(R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one;(R,E)-3,11-Dimethyl-8,9-dihydro-4H-4,7-(metheno)furo[3,2-c][1]oxacycloundecin-6(12H)-one;LWCKQMHMTSRRAA-QGQQYVBWSA-N;1312AC
SMILES:	CC1CC2=C(C(C)=CO2)[C@H]3C=C(CCC=1)C(=O)O3
Formula:	C15H16O3
M.Wt:	244.2857
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:	Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM[1][2].
In Vitro:	Linderalactone (0-100 μM; 24 hours; A549 cells) treatment inhibits the growth of A549 cells concentration-dependently. The IC50 of linderalactone is 15 µM[1]. Linderalactone (7.5-30 μM; A549 cells) treatment induces apoptosis in A549 cells in a dose-dependent manner[1]. Linderalactone (7.5-30 μM; 24 hours; A549 cells) treatment induces G2/M cell cycle arrest of A549 cells dose-dependently[1]. Linderalactone (7.5-30 μM; A549 cells) inhibits the expression of STAT1, JAK1 and JAK2. Linderalactone could also inhibit the phosphorylation of pSTAT1, pSTAT-2, pJAK1 and pJAk2[1]. Cell Viability Assay[1] Cell Line: Lung cancer A549 cells Concentration: 0 μM, 1.6 μM, 3.2 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Inhibited the growth of A549 cells concentration-dependently. Apoptosis Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Induced apoptosis in A549 cells in a dose-dependent manner. Cell Cycle Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: 24 hours Result: Induced G2/M cell cycle arrest. Western Blot Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Inhibited the JAK/STAT pathway in A549 cells.
References:	[1]. Deng Y, et al. Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G2/M cell cycle arrest and inhibition of JAK/STAT signalling pathway. J BUON. 2019 Mar-Apr;24(2):566-571. [2]. Qinghua Sun, et al. Preparative Isolation and Purification of Linderalactone and Lindenenol from Radix linderae by HSCCC. Journal of Liquid Chromatography & Related Technologies. Aug 2005:113-121.