SF-1-088|CAS 1241832-83-6|DC Chemicals

Cas No.:	1241832-83-6
Chemical Name:	SF-1-088
SMILES:	O=C(O)C1=CC=C(N(CC2=CC=CC=C2)C(CN(C(OC(C)(C)C)=O)S(=O)(C3=CC=C(C)C=C3)=O)=O)C=C1O
Formula:	C₂₈H₃₀N₂O₈S
M.Wt:	554.61

MSDS

Cat. No.	Product name	Field of application
DC45278	Colivelin	Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury
DC8726	FLLL31	FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway.
DC73591	WZ-2-033	WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling.
DC73590	WB737	WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM.
DC73589	WB436B	WB436B is a potent and highly selective small molecule inhibitor of STAT3, specifically targets the STAT3-SH2 domain with KD value of 94.3 nM.
DC73588	W2014-S	W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.
DC73587	W1131	W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo.
DC73586	W1046	W1046 is a potent and selective STAT3 inhibitor, decreases the expression of VISTA at mRNA and protein level and inhibits proliferation and survival in AML cells.
DC73585	TR120	TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
DC73584	SF-1-088	SF-1-088 is a small molecule STAT5-SH2 domain inhibitor with Ki of 8.3 uM (Stat5b), shows no affinity for Stat1 and Stat3 (Ki>25 uM).