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Home > Molecular Glues

TMX-4100

  Cat. No.:  DC47883   Featured
Chemical Structure
2367619-63-2
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More than 5000 active chemicals with high quality for research!
Field of application
TMX-4100 is a selective degrader of phosphodiesterase 6D (PDE6D), exhibiting high degradation efficiency with DC50 values below 200 nM in MOLT4, Jurkat, and MM.1S cells. It is a promising compound for research in multiple myeloma.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2367619-63-2
Chemical Name: 2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-
Synonyms: 2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-;TMX-4100;CS-0371240;2367619-63-2;3-(4-thiophen-3-yltriazol-1-yl)piperidine-2,6-dione;CHEMBL5091525;HY-145321;F83835;3-(4-(Thiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione;EX-A6059;AKOS040757594;DA-78516;MS-23693;GLXC-25097;SCHEMBL22711376
SMILES: N1C(=O)CCC(N2C=C(C3C=CSC=3)N=N2)C1=O
Formula: C11H10N4O2S
M.Wt: 262.29
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC67413 MRT-23227
DC67412 MRT-3486
DC67411 MRT-7612
DC67410 MRT-10350
DC67407 IKZF1-degrader-1 IKZF1-degrader-1 (Compound 9-B) is a highly potent molecular glue that achieves sub-nanomolar degradation of IKZF1 (DC50 = 0.134 nM), demonstrating significant therapeutic potential for targeting IKZF1-dependent malignancies.
DC67406 EM12-FS EM12-FS is a bifunctional CRBN modulator that engages cereblon at His353 while functioning as a molecular glue to induce NTAQ1 degradation. Demonstrating favorable pharmacokinetics, it exhibits a human plasma half-life of 196 minutes, supporting its therapeutic potential.
DC67405 Acetyl-cyclosporin A aldehyde Acetyl-cyclosporin A aldehyde is a chemically modified derivative of cyclosporin A (HY-B0579), featuring an acetyl group and a reactive aldehyde moiety. The parent compound, cyclosporin A, is a dual-function molecule that both inhibits calmodulin signaling and binds cyclophilin, thereby blocking NF-AT nuclear translocation and inducing mitochondrial dysfunction.
DC67404 QS-57 QS-57 is a bifunctional degrader that combines BRD4-targeting PROTAC activity with 14-3-3 molecular glue properties.
DC67403 KRAS ligand 4 KRAS ligand 4 (compound 2) is a SOS1-targeting bifunctional molecular glue that suppresses oncogenic signaling by degrading key KRAS pathway components, evidenced by reduced pERK and pS6 levels. It demonstrates broad-spectrum activity against diverse KRAS mutations, disrupting proliferation across resistant cancer models.
DC67402 Pomalidomide-15N,13C5 Pomalidomide-15N,13C5 is a stable isotope-labeled variant of pomalidomide (HY-10984), a third-generation immunomodulatory drug that functions as a cereblon-directed molecular glue. This compound mediates targeted ubiquitination and degradation of Ikaros family transcription factors (IKZF1/3) through recruitment of the CRL4CRBN E3 ligase complex, underpinning its therapeutic mechanism.
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