| DC8523 |
LY333531 Hydrochloride(Ruboxistaurin HCl)
Featured
|
LY-333,531 Hydrochloride is a potent, selective inhibitor of Protein Kinase C isozymes, PKC beta I (IC50 = 4.7 nM) and PKC beta II (IC50 = 5.9 nM). It is potentially beneficial for cancer research. |
|
| DC9190 |
Manidipine Dihydrochlorid |
Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. |
|
| DC11315 |
Manidipine(CV-4093) |
Manidipine is a dihydropyridine L- and T-type calcium channel blocker. |
|
| DC9191 |
Metoprolol tartrate |
Metoprolol is a cardioselective β1-adrenergic blocking agent. |
|
| DC1009 |
Laropiprant
Featured
|
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respectively. |
|
| DC9456 |
MK-0354 |
MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.
|
|
| DC5177 |
Nepicastat HCl (SYN-117)
Featured
|
Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
|
| DC9796 |
Nicainoprolhe(Nicainoprol)
Featured
|
Nicainoprolhe is an antiarrhythmic agent,a fast-sodiumchannel blocking drug (class Ib), also protected isolated rat hearts against reperfusion arrhythmias. |
|
| DC9170 |
Nicardipine hydrochloride |
Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. |
|
| DC9108 |
Nisoldipine |
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. |
|
| DC10134 |
Obicetrapib (AMG-899,TA-8995)
Featured
|
Obicetrapib is a CETP inhibitor, on the elevation of high-density lipoprotein cholesterol (HDL-C) and reduction of low-density lipoprotein cholesterol (LDL-C), alone and in combination with statin therapy. |
|
| DCAPI1464 |
Olmesartan |
Olmesartan Acid is an angiotensin II receptor antagonist that prevents the binding of angiotensin II, thus preventing vasoconstriction. |
|
| DC9179 |
Olmesartan MedoxoMil |
Olmesartan medoxomil(Olmetec; Benicar; CS 866) is an angiotensin II receptor antagonist which is used as an anti-hypertensive. |
|
| DC10324 |
Omapatrilat |
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively. |
|
| DC9443 |
Otamixaban |
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.
|
|
| DC7970 |
ACT058362 (Palosuran)
Featured
|
Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM. |
|
| DC7224 |
PD 123319
Featured
|
PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. |
|
| DC11360 |
Pemafibrate
Featured
|
Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis. |
|
| DC10500 |
PF-06282999
Featured
|
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases. |
|
| DC10012 |
Pirmenol hydrochloride
Featured
|
Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM. |
|
| DC6903 |
Lapaquistat Acetate (TAK-475) |
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. |
|
| DC11138 |
Guanabenz acetate |
R15A inhibitor. |
|
| DC5108 |
BAY 59-7939 (Rivaroxaban)
Featured
|
Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. |
|
| DC9666 |
Ro 46-2005
Featured
|
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. |
|
| DC7933 |
Ro 48-8071 fumarate
Featured
|
Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. |
|
| DC7490 |
Rostafuroxin
Featured
|
Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. |
|
| DC9313 |
Sarpogrelate (hydrochloride)
Featured
|
Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
|
|
| DC10700 |
Seladelpar
Featured
|
Seladelpar is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. |
|
| DCAPI1349 |
Simvastatin (Zocor)
Featured
|
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. |
|
| DC4108 |
Sitaxentan sodium
Featured
|
Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively. |
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