E3 ligase Ligand 1 dihydrochloride |CAS 2504950-56-33|DC Chemicals

Cas No.:	2504950-56-3
Chemical Name:	(2S,4R)-1-(2S)-2-amino-3,3-dimethylbutanoyl-4-hydroxy-N-(1S)-1-4-(4-methyl-1,3-thiazol-5-yl)phenylethylpyrrolidine-2-carboxamide dihydrochloride
Synonyms:	E3 ligase Ligand 1 dihydrochloride;(S,R,S)-AHPC-Me (dihydrochloride);(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide dihydrochloride;VHL ligand 2 dihydrochloride;AMY27708;ZB0749;Z4505488455;(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-;(2S,4R)-1-(2S)-2-amino-3,3-dimethylbutanoyl-4-hydroxy-N-(1S)-1-4-(4-methyl-1,3-thiazol-5-yl)phenylethylpyrrolidine-2-carboxamide dihydrochloride:YAN50563
SMILES:	Cl.Cl.S1C=NC(C)=C1C1C=CC(=CC=1)[C@H](C)NC([C@@H]1C[C@H](CN1C([C@H](C(C)(C)C)N)=O)O)=O
Formula:	C₂₃H₃₄Cl₂N₄O₃S
M.Wt:	517.512062549591
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vitro E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. E3 ligase Ligand 1 is a part of the active BRD4 PROTAC ARV-771, wich is a potent pan-BET degrader with antitumor activity.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC39709	Lenalidomide-Br	Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.
DC72888	Z0933M	Z0933M is a potent S phase kinase-associated protein 1 (Skp1) inhibitor with Kd of 54 nM, potently inhibits Skp1-F-box protein-protein interactions with Ki value of 231 nM in FP-based in vitro competition assays.
DC72103	CC-99282	CC-99282 (Golcadomide) is an orally active cereblon (CRBN) E3 ligase modulator (CELMoD). Ikaros and Aiolos are degraded potently and specifically by CC-99282, which co-opts CRBN.
DC46257	N-Boc-SBP-0636457-OH	N-Boc-SBP-0636457-OH, a ligand for E3 ubiquitin ligase, is used in the recruitment of IAP E3 ligases. N-Boc-SBP-0636457-OH can be connected to the ligand for Bcl-xL by a linker to form PROTAC Bcl-xL degrader-1.
DC44854	β-Naphthoflavone-CH2-Br	β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1.
DC42559	Piperidine-GNE-049-N-Boc	Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.
DC42464	CRBN modulator-1	CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.
DC42463	Thalidomide-NH-CH2-COOH	Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032.
DC42462	Lenalidomide-I	Lenalidomide-I (Compound 72) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570.
DC28693	CC-90009	CC-90009 is a cereblon modulator. CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. .