| DC24055 |
Agomelatine L(+)-Tartaric acid
Featured
|
A melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
|
| DC26095 |
QX 314 chloride
Featured
|
A membrane-impermeable sodium channel blocker, blocks sodium current in voltage-clamped nociceptive DRG neurons. |
|
| DC23973 |
F16
Featured
|
A mitochondriotoxic small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. |
|
| DC11530 |
Tapinarof (Benvitimod; GSK2894512)
Featured
|
Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice. |
|
| DC11658 |
Diptoindonesin G
Featured
|
Dip G is a natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ. |
|
| DC25093 |
Neuromedin N
Featured
|
A neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.. |
|
| DC11892 |
Elsulfavirine
Featured
|
A new-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV-1 infections, the prodrug of the active compound VM-1500A.. |
|
| DC23907 |
Polyoxyethylene 40 stearate
Featured
|
A non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity. |
|
| DCAPI1496 |
Ambrisentan
Featured
|
A nonpeptide endothelin ETA receptor antagonist. Antihypertensive. |
|
| DC22911 |
AH-3960
Featured
|
A non-peptide small molecule agonist of the PTH1 receptor, activates both the cAMP and calcium signaling pathways.. |
|
| DC24049 |
Anamorelin fumarate
Featured
|
A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects. |
|
| DC24050 |
Anamorelin hydrochloride
Featured
|
A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects. |
|
| DC22619 |
Rotigotine
Featured
|
A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM). |
|
| DC23203 |
E4CPG
Featured
|
A non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist.. |
|
| DC11919 |
Arimoclomol
Featured
|
A nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
| DC11920 |
Arimoclomol maleate
Featured
|
A nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
| DC22587 |
FT011
Featured
|
FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis. |
|
| DC11534 |
Sudoterb
Featured
|
A novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.. |
|
| DC11521 |
Dotinurad
Featured
|
Dotinurad is a novel compound that exhibits a remarkable uric acid excretion-promoting action. |
|
| DC8784 |
CTLA-4 inhibitor
Featured
|
A novel CTLA-4 inhibitor. |
|
| DC22975 |
GB111-NH2
Featured
|
GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S.
GB111-NH2 (Z-Phe-Lys-AOMK) inhibits autophagy and increases oxidative stress, specifically trigger macrophage cell death. |
|
| DC10706 |
Ehp-inhibitor-2
Featured
|
A novel Ehp inhibitor |
|
| DC10705 |
Ehp-inhibitor-1
Featured
|
A novel Ehp inhibitor |
|
| DC22487 |
Benzenepentacarboxylic Acid
Featured
|
Benzenepentacarboxylic acid is a fluorescent dye that detects and scavenge HO radicals. |
|
| DC22768 |
MP07-66
Featured
|
A novel FTY720 analog that acts as PP2A activator, disrupts the SET/PP2A interaction devoid of immunosuppressive effects leads to the reactivation of PP2A. |
|
| DC22944 |
NS-3623
Featured
|
A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation). |
|
| DC25013 |
ARM-1
Featured
|
A novel LTA4 hydrolase (LTA4H) inhibitor that inhibits LTB4 synthesis in human neutrophils with IC50 of 0.5 uM. |
|
| DC10801 |
AMPA/kainate antagonist-1
Featured
|
A novel Non-competitive AMPA/kainate antagonist. |
|
| DC10808 |
AMPA/kainate antagonist-3
Featured
|
A novel Non-competitive AMPA/kainate antagonist. |
|
| DC24203 |
P2X2/3 receptor antagonist
Featured
|
A novel P2X3 and P2X2/3 receptor antagonist useful for the treatment
of urinary tract diseases, pain, respiratory diseases and cardiovascular diseases. |
|
