Cat. No. | Product name | CAS No. |
DC8188 |
Daprodustat
Featured
Daprodustat(GSK1278863) isa HIF-prolyl hydroxylase inhibitor. |
960539-70-2 |
DC7396 |
DAPT
Featured
DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma. |
208255-80-5 |
DC1050 |
Daptomycin
Featured
Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
103060-53-3 |
DC7397 |
Darapladib
Featured
Darapladib is a selective and orally active inhibitor of Lp-PLA2 (IC50= 270 pM) |
356057-34-6 |
DC8908 |
Darunavir ethanolate
Featured
Darunavir ethanolate is an HIV protease inhibitor,showed potent activity against COVID-19(SARS-COV-2). |
635728-49-3 |
DC12498 |
S-Darusentan
Featured
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries. |
171714-84-4 |
DC8647 |
DASA-58
Featured
DASA-58 is a highly specific small molecule PKM2 activator. DASA-58 inhibits LPS-induced Hif-1a and IL-1b, as well as the expression of a range of other Hif-1a-dependent genes. |
1203494-49-8 |
DC2100 |
Dasatinib (BMS-354825)
Featured
Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.5 nM and 79 nM, respectively. |
302962-49-8 |
DC3140 |
Dasatinib monohydrate
Featured
Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. |
863127-77-9 |
DC10073 |
Dasotraline Hydrochloride
Featured
Dasotraline is a stereoisomer of desmethylsertraline, which is an active metabolite of the marketed selective serotonin reuptake inhibitor (SSRI) antidepressant sertraline (Zoloft) and an SNDRI similarly. |
675126-08-6 |
DC8162 |
Dasotraline(SEP-225289) free base
Featured
Dasotraline(SEP-225289) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. |
675126-05-3 |
DC20229 |
Datelliptium chloride
Featured
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities. |
105118-14-7 |
DC7069 |
Daunorubicin HCL
Featured
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. |
23541-50-6 |
DC25058 |
Daunorubicin
Featured
Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells. |
20830-81-3 |
DC8826 |
DB07268
Featured
DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM. |
929007-72-7 |
DC23251 |
DB213
Featured
DB213 (RG-501) is a small molecule stimulator of HIV-1 frameshifting and inhibitor of viral replication. |
209163-39-3 |
DC22069 |
DB818
Featured
DB818 (DB-818, DB 818) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence. |
790241-43-9 |
DC21890 |
DBCO intermidate 3
Featured
DBCO intermidate 3 is a Click Chemistry intermidate used for antibody-drug conjugates.. |
1369862-03-2 |
DC7602 |
DBeQ
Featured
DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM. |
177355-84-9 |
DC12023 |
dBET1
Featured
dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM. |
1799711-21-9 |
DC21893 |
dBET57
Featured
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.. |
1883863-52-2 |
DC12022 |
dBET6
Featured
dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM, and has antitumor activity. |
1950634-92-0 |
DC12665 |
DBPR114
Featured
DBPR114 is a quinazoline-based multi-kinase inhibitor for the treatment of acute myeloid leukemia and other solid tumors. |
|
DC7790 |
CB1-IN-1(BPRCB1184)
Featured
CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively. IC50 value: 0.3 nM (Ki, CB1R) 21 nM (Ki, CB2R) Target: CB1R in vivo: CB1-IN-1 is a novel peripherally restricted cannabinoid 1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice. CB1-IN-1 has great potential to ameliorate this related metabolic syndrome. |
1429239-98-4 |
DC11589 |
dBRD9
Featured
dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex. |
2170679-45-3 |
DC23977 |
DC-05
Featured
DC-05 is a selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 10.3 uM, displays 3.6-fold selectivity over PRMT1 and >15-fold over DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9.. |
890643-16-0 |
DC20945 |
DC_AC50
Featured
DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation. |
497061-48-0 |
DC10554 |
DC260126
Featured
DC260126, a small-molecule antagonist of GPR40. |
346692-04-4 |
DC12554 |
DC661
Featured
DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1). |
1872387-43-3 |
DC5041 |
DCC-2036 (Rebastinib)
Featured
DCC-2036 is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1/2. |
1020172-07-9 |
DC9585 |
c-Kit-IN-1(DCC-2618)
Featured
DCC-2618 is a small molecule inhibitor of c-Kit and PDGFR with IC50s of 6 nM/30 nM/13 nM for c-Kit/PDGFRα/PDGFRβ respectively. |
1225278-16-9 |
DC20175 |
Ripretinib (DCC-2618)
Featured
DCC-2618 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) KIT and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM. |
1442472-39-0 |
DC20947 |
DDD 85646
Featured
DDD 85646 is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively. |
1215010-55-1 |
DC10996 |
DDR inhibitor X
Featured
DDR inhibitor X is a potent discoidin domain receptor (DDR) inhibitor with IC50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.. |
1644069-80-6 |
DC7398 |
DDR1-IN-1
Featured
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM). |
1449685-96-4 |
DC7390 |
CUDC-305(DEBIO 0932)
Featured
Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L) . |
1061318-81-7 |
DC8171 |
Decernotinib (VX-509,adelatinib)
Featured
Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. |
944842-54-0 |
DC4193 |
Decitabine
Featured
Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
2353-33-5 |
DC12144 |
Decursin ((+)-Decursin)
Featured
Decursin is an anticancer agent, with potential anti-inflammatory activity. |
5928-25-6 |
DC7695 |
Defactinib (VS-6063, PF-04554878)
Featured
Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel. |
1073154-85-4 |
DC10100 |
Defactinib hydrochloride
Featured
Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel. |
1073160-26-5 |
DC10822 |
Defensamide(MHP)
Featured
Defensamide, also known as MHP and methyl caprooyl tyrosinate, is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC. |
1104874-94-3 |
DCAPI1107 |
Deferasirox (Exjade)
Featured
Deferasirox (Exjade) |
201530-41-8 |
DC7399 |
Deferitrin
Featured
Deferitrin (GT-56-252) is the first drug in a class of desferrithiocin-derived hexadentate iron chelators. |
239101-33-8 |
DC11332 |
Degarelix (acetate)
Featured
Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist (IC50 = 3 nM in HEK293 cells expressing the human receptor). |
214766-78-6 |
DC9337 |
Deguelin
Featured
Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers; decrease levels of phosphorylated Akt. |
522-17-8 |
DC8866 |
DEL-22379
Featured
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
181223-80-3 |
DC10458 |
Delafloxacin(ABT-492)
Featured
Delafloxacin (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent. |
189279-58-1 |
DC20116 |
Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine)
Featured
Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and |
352458-37-8 |
DC7764 |
Delamanid (OPC-67683)
Featured
Delamanid (OPC-67683) is an experimental drug for the treatment of multi-drug-resistant tuberculosis. |
681492-22-8 |
DC8481 |
Delanzomib(CEP-18770)
Featured
Delanzomib(CEP-18770) is a novel orally-active inhibitor of the chymotrypsin-like activity of the proteasome that down-modulates the nuclear factor-kappaB (NF-kappaB) activity. |
847499-27-8 |
DC11890 |
Delgocitinib
Featured
Delgocitinib (JTE-052, LEO 124249) is a potent, selective, orally active, pan-JAK inhibitor with IC50 of 2.8, 2.6, 13 and 58 nM for JAK1,2,3 and Tyk2, respectively. |
1263774-59-9 |
DC10612 |
Delpazolid (LCB01-0371)
Featured
Delpazolid (LCB01-0371) is a new oxazolidinone with cyclic amidrazone. |
1219707-39-7 |
DC8205 |
Deltarasin
Featured
Deltarasin is a novel and small molecule inhibitor which can inhibit the KRAS-PDEδ interaction(Kd= 41 nM. binding to PDEδ) and impairs oncogenic KRAS signalling. |
1440898-61-2 |
DC26004 |
delta-Valerobetaine (hydrobromide)
Featured
Delta-Valerobetaine (hydrobromide) is a precursor of trimethylamine N-oxide (TMAO). |
66258-96-6 |
DC12287 |
delta-Valerobetaine
Featured
Delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO). |
6778-33-2 |
DC8712 |
Deoxycorticosterone acetate
Featured
Deoxycorticosterone acetate is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. |
56-47-3 |
DC10559 |
Derazantinib (ARQ 087)
Featured
Derazantinib (Derazantinib) is an ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 4.5, 1.8, and 4.5 nM, respectively. |
1234356-69-4 |
DC24197 |
Derenofylline(SLV320)
Featured
Derenofylline(SLV320) is a potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). |
251945-92-3 |
DC11402 |
Desidustat
Featured
Desidustat is an inhibitor of HIF hydroxylase. |
1616690-16-4 |
DC11055 |
Desmethyl dabrafenib
Featured
Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo.. |
1195765-47-9 |
DC8833 |
Desmethyl VS-5584
Featured
Desmethyl VS-5584 is a PI3K/mTOR kinase inhibitor |
1246535-95-4 |
DC9604 |
Desogestrel
Featured
Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP). |
54024-22-5 |
DC20273 |
Deuterated AZ5104
Featured
Deuterated AZ5104 is a potent EGFR inhibitor. |
2129998-32-7 |
DCAPI1025 |
Dexamethasone
Featured
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs used as an anti-inflammatory and immunosuppressant. |
50-02-2 |
DC4240 |
Dexmedetomidine hydrochloride
Featured
Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties. |
145108-58-3 |
DC22074 |
DFP00173
Featured
DFP00173 (DFP-00173) is a potent and selective aquaporin-3 (AQP3) inhibitor, inhibits glycerol permeability in erythrocytes with IC50 of 0.2 uM.. |
672286-03-2 |
DC24079 |
DG-172 dihydrochloride
Featured
DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties. |
1361504-77-9 |
DC12321 |
STING agonist-1 trihydrochloride
Featured
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist. |
2138299-34-8 |
DC10060 |
Dianilinopyrimidine_01(CZC8004)
Featured
Dianilinopyrimidine_01 is a Pan Tyrosine kinase inhibitor. |
916603-07-1 |
DC23201 |
Diarylpropionitrile
Featured
Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture. |
1428-67-7 |
DC20153 |
Dibutyl phthalate
Featured
Dibutyl phthalate is a commonly used plasticizer commonly found in some food packaging materials, personal care products, and the coating of oral medications. May cause toxicity and adverse neurobehavioral effects. |
84-74-2 |
DC8394 |
Dibutyryl-cAMP (Bucladesine)
Featured
Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. |
16980-89-5 |
DCAPI1032 |
Dichlorphenamide (Diclofenamide)
Featured
Dichlorphenamide (Diclofenamide) |
120-97-8 |
DCAPI1300 |
Diclofensine (Ro 8-4650)
Featured
Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. |
67165-56-4 |
DC8827 |
Didox
Featured
Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers. |
69839-83-4 |
DC21445 |
Difamilast
Featured
Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). |
937782-05-3 |
DC9551 |
Difluprednate
Featured
Difluprednate(Durezol) is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain. |
23674-86-4 |
DC12167 |
Digitonin
Featured
Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. |
11024-24-1 |
DC9760 |
Dihexa (PNB-0408)
Featured
Dihexa is an oligopeptide drug that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. |
1401708-83-5 |
DC8274 |
Dihydroethidium
Featured
Dihydroethidium(Hydroethidine; PD-MY 003) is a superoxide indicator; exhibits blue-fluorescence in the cytosol until oxidized, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red. |
104821-25-2 |
DC10446 |
(3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride
Featured
Diltiazem hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). |
120205-48-3 |
DC20223 |
DIM-C-pPhCO2Me
Featured
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist with antineoplastic activity. |
151358-48-4 |
DC10791 |
DIM-C-pPhOH(CDIM8)
Featured
DIM-C-pPhOH is a Nur77 Antagonist. DIM-C-pPhOH inhibits lung cancer cell and tumor growth in a metastasis model. |
151358-47-3 |
DC8722 |
Dimethoxycurcumin(DiMC)
Featured
Dimethoxycurcumin is an analog of curcumin obtained by methylation of both free phenolic groups in the parent compound. |
160096-59-3 |
DC20147 |
Dimethyl 4-hydroxyisophthalate
Featured
Dimethyl 4-hydroxyisophthalate is a methyl salicylate analogue. |
5985-24-0 |
DC7114 |
Dinaciclib (SCH727965)
Featured
Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. |
779353-01-4 |
DC23155 |
Dinoprost tromethamine salt
Featured
Dinoprost (Prostaglandin F2α, PGF2α) is a naturally occurring prostaglandin used to induce labor and as an abortifacient, causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.. |
38562-01-5 |
DC9863 |
Dinoprost
Featured
Dinoprost(Prostaglandin F2α) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. |
551-11-1 |
DC9834 |
Dioscin
Featured
Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. |
19057-60-4 |
DC26047 |
Dipeptide diaminobutyroyl benzylamide (acetate)
Featured
Dipeptide diaminobutyroyl benzylamide is a biomimetic peptide and a muscarinic acetylcholine receptor antagonist. |
823202-99-9 |
DCAPI1702 |
Diphemanil methylsulfate
Featured
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR). |
62-97-5 |
DC26059 |
Diprotin A
Featured
Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 |
90614-48-5 |
DC10343 |
Diquafosol tetrasodium
Featured
Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease. |
211427-08-6 |
DC23302 |
Disarib
Featured
Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.). |
1998149-15-7 |
DC8385 |
Disodium (R)-2-Hydroxyglutarate
Featured
Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. |
103404-90-6 |
DCAPI1398 |
Disulfiram (Antabuse)
Featured
Disulfiram (Antabuse) |
97-77-8 |
DC7960 |
(+)MK-801 maleate
Featured
Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM |
77086-22-7 |
DC23122 |
DiZPK
Featured
DiZPK is a genetically encoded, highly efficient photocrosslinking amino acid valuable in unveiling the physiological interaction partners of given proteins and their functions.. |
1337883-32-5 |
DC22216 |
DJ4
Featured
DJ4 (ROCK inhibitor DJ4) is a potent, selective, ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM, respectively. |
1681020-24-5 |
DC12040 |
DJ-V-159
Featured
DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A). |
2253744-53-3 |
DC12442 |
DK419
Featured
DK419 (DK-419) a potent, orally acitve inhibitor of Wnt/β-catenin signaling with IC50 of 0.19 uM in Wnt3A-stimulated TOPFlash assays. |
2102672-22-8 |
DC10550 |
DKM 2-93
Featured
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM. |
65836-72-8 |
DC10707 |
DL-AP4
Featured
DL-AP4 is a Broad spectrum EAA antagonist. |
6323-99-5 |
DC10708 |
DL-AP5
Featured
DL-AP5 is a Broad spectrum EAA antagonist. |
76326-31-3 |
DC10709 |
DL-AP5 Sodium salt
Featured
DL-AP5 is a Broad spectrum EAA antagonist. |
1303993-72-7 |
DC9250 |
DL-AP7
Featured
DL-AP7 is a competitive antagonist of the ionotropic glutamate receptor, NMDA. |
85797-13-3 |
DC12145 |
DLinDMA
Featured
DLinDMA is a key lipid component of stable nucleic acid lipid particles as a benchmark. |
871258-12-7 |
DC12381 |
DLin-KC2-DMA
Featured
DLin-KC2-DMA is 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA. |
1190197-97-7 |
DC11486 |
D-Luciferin (potassium salt)
Featured
D-Luciferin is a chemiluminescent substrate of firefly luciferase. |
115144-35-9 |
DC9287 |
D-Luciferin
Featured
D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. Cas: 2591-17-5 |
2591-17-5 |
DC11426 |
DM1-PEG4-DBCO
Featured
DM1-(PEG)4-DBCO (DBCO-PEG4-DM1) is made by DM1 conjugated to DBCO-(PEG)4 linker.DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent. |
|
DC8539 |
DM1-SMCC
Featured
DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate. |
1228105-51-8 |
DC11396 |
DM1-SMe
Featured
DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. |
138148-68-2 |
DC9401 |
DMAT(CK2 Inhibitor)
Featured
DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM. |
749234-11-5 |
DC7643 |
DMH1
Featured
DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. |
1206711-16-1 |
DC7403 |
Dimethyloxaloylglycine(DMOG)
Featured
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). |
89464-63-1 |
DC20600 |
DM-PIT-1
Featured
DM-PIT-1 is a specific PIP3 antagonist that disrupts PIP3/Akt PH domain, PIP3/PDK1 PH domain, and PIP3/GRP1 PH domain with IC50 of 27.1 uM, 80.5 uM, and 35.5 uM, respectively. |
701947-53-7 |
DC11473 |
DMU-2105(CYP1B1 inhibitor 7k)
Featured
DMU-2105(CYP1B1 inhibitor 7k) is a potent and specific CYP1B1 inhibitor. |
1031063-36-1 |
DC22291 |
DMU-212(resveratrol analog)
Featured
DMU-212, a methoxylated resveratrol analog, has significant anticancer activity, and selectively targets tumor cells. |
134029-62-2 |
DC22307 |
DMX-5804
Featured
DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). |
2306178-56-1 |
DC7404 |
DMXAA
Featured
DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. Phase 3. |
117570-53-3 |
DC11348 |
MMP-1/MMP-9 Fluorogenic Substrate
Featured
Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9 |
150956-92-6 |
DC11351 |
MMP-1 Fluorogenic Substrate I
Featured
Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8. |
135662-04-3 |
DC11339 |
MMP-8/MMP-26 Fluorogenic Substrate
Featured
Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26.The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitro |
135662-05-4 |
DC11347 |
MMP-1 Substrate II
Featured
Dnp-PLG-Cys(Me)-HA-DArg-NH2 is a peptide substrate for matrix metalloproteinase-1 (MMP-1).It has an improved kcat/Km ratio compared with the MMP-1 flurogenic substrate Dnp-PLGLWA-DArg-NH2. |
145224-98-2 |
DC10673 |
DNQX disodium salt
Featured
DNQX is a elective non-NMDA antagonist |
1312992-24-7 |
DC10672 |
DNQX
Featured
DNQX is a elective non-NMDA antagonist |
2379-57-9 |
DC11464 |
DO-264
Featured
DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM).It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells. |
2301866-59-9 |
DC4187 |
Docetaxel
Featured
Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
114977-28-5 |
DC9648 |
Dodecanoic acid ingenol ester
Featured
Dodecanoic acid ingenol ester is a natural compound. |
54706-70-6 |
DC12216 |
Dodecanoylcarnitine
Featured
Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. |
25518-54-1 |
DCAPI1022 |
Dofetilide (Tikosyn)
Featured
Dofetilide (Tikosyn) |
115256-11-6 |
DC7273 |
Dolutegravir
Featured
Dolutegravir (DTG, GSK1349572) is an integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. |
1051375-16-6 |
DC10250 |
Dolutegravir Sodium
Featured
Dolutegravir is a HIV integrase inhibitor with IC50 of 2.7 nM. |
1051375-19-9 |
DC3155 |
Donepezil hydrochloride
Featured
Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
120011-70-3 |
DC11103 |
Tavapadon
Featured
Tavapadon is a potent, orally-bioavailable, selective partial agonist of the dopamine D1 and D5 receptors. |
1643489-24-0 |
DC9308 |
Doravirine (MK-1439)
Featured
Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor. |
1338225-97-0 |
DC7115 |
Dorsomorphin dihydrochloride
Featured
Dorsomorphin 2Hcl (Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits ALK2, ALK3, and ALK 6 . |
1219168-18-9 |
DC3142 |
Dovitinib Dilacticacid
Featured
Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively. |
852433-84-2 |
DC4157 |
Dovitinib (TKI258, CHIR258)
Featured
Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively. |
405169-16-6 |
DC3141 |
Dovitinib (TKI258) Lactate
Featured
Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively. |
915769-50-5 |
DC9664 |
Doxapram
Featured
Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
309-29-5 |
DCAPI1241 |
Doxercalciferol (Hectorol)
Featured
Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
54573-75-0 |
DC4188 |
Doxorubicin hydrochloride
Featured
Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
25316-40-9 |
DC8383 |
Dp44mT
Featured
Dp44mT is a potent iron chelator, which shows selective antitumor activity. |
152095-12-0 |
DC20966 |
DPM-1001
Featured
DPM-1001 is a potent, selective, orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B with IC50 of 100 nM, also chelates copper, which enhanced its potency as a PTP1B inhibitor. |
1471172-27-6 |
DC9949 |
DprE1-IN-2
Featured
DprE1-IN-2 is a potent DprE1 inhibitor. |
1615713-87-5 |
DC11173 |
DRAinh-A250
Featured
DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM. |
858747-13-4 |
DC10039 |
DREADD Agonist 21
Featured
DREADD agonist 21 is a potent muscarinic hM3Dq DREADD agonist (EC50 = 1.7 nM). Highly selective for hM3Dq DREADDs over endogenous hM3 receptors. |
56296-18-5 |
DC20103 |
D-Ribose(mixture of isomers)
Featured
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation |
50-69-1 |
DCAPI1562 |
Drospirenone
Featured
Drospirenone is a synthetic progestogen exhibiting antiandrogenic and antimineralocorticoid activity. |
67392-87-4 |
DC2056 |
Droxidopa (L-DOPS,SM-5688)
Featured
Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). |
23651-95-8 |
DC8350 |
Droxinostat
Featured
Droxinostat is a selective HDAC3, HDAC6 and HDAC8 inhibitor. |
99873-43-5 |
DC20975 |
DS-2330
Featured
DS-2330 is a phosphorous lowering agent for treating hyperphosphatemia in chronic kidney disease.. |
1634680-81-1 |
DC11726 |
Milademetan
Featured
Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis. |
1398568-47-2 |
DC12410 |
8-{1-[(1R,4R)-4-aminocyclohexyl]ethenyl}-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine
Featured
DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM. |
|
DC22082 |
DS-437
Featured
DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases. |
1674364-87-4 |
DC12411 |
DS-6930
Featured
DS-6930 (DS 6930, DS6930) is a novel potent, selective PPARγ agonist with EC50 of 41 nM, Emax-68%; significantly recruits several cofactors, such as RIP140 and PGC1, in cofactor recruitment assays; demonstrateshigh PPARγ agonist potency with robust plasma glucose reduction, maintains diminished PPARγ-related adverse effects upon toxicological evaluation in vivo, and demonstrated no hepatotoxicity. |
1242328-82-0 |
DC20976 |
DS-7423
Featured
DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively. |
1222104-37-1 |
DC11409 |
DSM265
Featured
DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM. |
1282041-94-4 |
DC26008 |
DSP2230
Featured
DSP-2230 is a selective Nav1.7/Nav1.8 blocker. |
1233231-30-5 |
DC20367 |
dTRIM24
Featured
dTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement). |
2170695-14-2 |
DC3148 |
Duloxetine
Featured
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
116539-59-4 |
DC8825 |
Dutasteride
Featured
Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). |
164656-23-9 |
DC10805 |
DWK-1339
Featured
DWK-1339|DWK1339|cas 1018946-38-7 |
1018946-38-7 |
DC7405 |
DY131
Featured
DY131(GSK 9089) is a novel selective agonist of ERRβ and ERRγ; displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. |
95167-41-2 |
DC20368 |
Dynarrestin
Featured
Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis. |
2222768-84-3 |
DC7406 |
Dynasore
Featured
Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. |
304448-55-3 |
DC8396 |
Dyngo-4a
Featured
Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. |
1256493-34-1 |
DC8277 |
E-2012
Featured
E 2012 is a potent γ-secretase modulator. |
870843-42-8 |
DC20986 |
E 6446
Featured
E 6446 is a novel orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
1219925-73-1 |
DC11213 |
E1231
Featured
E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα). |
1031195-19-3 |
DC10895 |
E260
Featured
E260 is a Fer/FerT kinase inhibitor. |
1241537-79-0 |
DC22335 |
E3 ligase Ligand 1A
Featured
E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer. (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) |
1948273-02-6 |
DC11565 |
E3 Ligase Ligand 2
Featured
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology. |
5054-59-1 |
DC11571 |
E3 Ligase Ligand 3
Featured
E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology. |
1061605-21-7 |
DC12674 |
E3 ligase Ligand-Linker Conjugates 16
Featured
E3 ligase Ligand-Linker Conjugates 16 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
1799711-25-3 |
DC12675 |
E3 ligase Ligand-Linker Conjugates 17
Featured
E3 ligase Ligand-Linker Conjugates 17 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
1950635-16-1 |
DC12141 |
E3 Ligase Ligand-Linker Conjugates 22
Featured
E3 Ligase Ligand-Linker Conjugates 22 incorporates an E3 ligase ligand and a linker, can be used for the treatment of EZH2-mediated cancer. |
2225940-52-1 |
DC8404 |
E3330
Featured
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
136164-66-4 |
DC7128 |
Lucitanib(E3810)
Featured
E-3810 is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. |
1058137-23-7 |
DC9595 |
E-4031
Featured
E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel. |
113559-13-0 |
DC10141 |
E6005
Featured
E6005 potently and selectively inhibited human PDE4 activity with an IC50 of 2.8 nM and suppressed the production of various cytokines from human lymphocytes and monocytes with IC50 values ranging from 0.49 to 3.1 nM. |
947620-48-6 |
DC9387 |
E-64
Featured
E-64 is a natural, potent, and irreversible inhibitor of cysteine proteases; IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively. |
66701-25-5 |
DC10520 |
E6446 dihydrochloride
Featured
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. |
1345675-25-3 |
DC10126 |
E-64c
Featured
E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillus japonicus. |
76684-89-4 |
DC8485 |
E-64d(Aloxistatin)
Featured
E-64D is an inhibitor of cathepsins B and L; also thought to inhibit calpain,showed a potent activity for COVID-19(SARS-COV-2)with EC50: MERS-COV(1.275),SARS-COV(0.760) |
88321-09-9 |
DC10563 |
E-7046
Featured
E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities. |
1369489-71-3 |
DC5065 |
Golvatinib (E7050)
Featured
E-7050 is hepatocyte growth factor receptors (HGFR). |
928037-13-2 |
DC8488 |
LENVATINIB MESYLATE
Featured
E7080 (Lenvatinib) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β. |
857890-39-2 |
DC7116 |
E7080 (Lenvatinib)
Featured
E7080 (Lenvatinib; Vargatef) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β. |
417716-92-8 |
DC10976 |
E-7386
Featured
E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively. |
1799824-08-0 |
DC9983 |
E-7449
Featured
E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2; enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. |
1140964-99-3 |
DC10784 |
E7820
Featured
E7820 is an angiogenesis inhibitor by suppressing integrin a2, a cell adhesion molecule expressed on endothelial cells. |
289483-69-8 |
DC9665 |
EAI045
Featured
EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants but spares the wild-type receptor. |
1942114-09-1 |
DC9534 |
EBE-A22
Featured
EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. |
229476-53-3 |
DC11477 |
EBI-2511
Featured
EBI-2511 is a highly potent and orally active EZH2 inhibitor for the treatment of Non-Hodgkin’s Lymphoma. |
2098546-05-3 |
DC9848 |
Ebselen
Featured
Ebselen is a selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. |
60940-34-3 |
DC10277 |
EC330
Featured
EC330 is a leukemia inhibitory factor (LIF) inhibitor. |
2016795-77-8 |