| DC82032 |
Methoxy-X04
Featured
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Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. |
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| DC60333 |
BRD7586
Featured
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BRD-7586(BRD 7586) is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2 µM and 5.7 µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci. |
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| DC82050 |
Coelenterazine H
Featured
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Coelenterazine h is a derivative of Coelenterazine. Coelenterazine h is more sensitive to Ca2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca2+ concentrations. |
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| DC60335 |
Centanamycin
Featured
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Centanamycin alkylates the A-T-rich minor groove of the DNA and thereby blocks DNA replication. Centanamycin potently inhibits replication of human cytomegalovirus (HCMV), mouse CMV (MCMV), and herpes simplex virus-2 (HSV-2) in vitro. Centanamycin-attenuated whole virion MCMV elicits a robust serum neutralizing antibody response and protects the mice from live-virus challenge. |
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| DC86070 |
304-O13 (Trimidin)
Featured
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304O13 is a novel Biodegradable lipidoid for RNA delivery. |
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| DC81075 |
CSL3
Featured
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| DC60336 |
UT-143
Featured
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UT-143 is a selective androgen receptor irreversible covalent antagonist and inhibits AR transactivation with IC50 of 150 nM. UT-143 covalently and selectively binds to C406 and C327 in the AF-1 region and inhibits PCa cell proliferation and tumor growth. |
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| DC60337 |
A947
Featured
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A947 is a potent and selective SMARCA2 PROTAC with DC50 of 39 pM in W1573 cells. A947 shows 28-fold selectivity over SMARCA4 and notably exhibits no unexpected off-target effects at high concentration. |
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| DC72286 |
Fomivirsen
Featured
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Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation. |
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| DC72290 |
DVR-01
Featured
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DVR-01 is a HBV inhibitor with EC50 values of 1.7 and 1.6 μM in AML12HBV10 and HepDES19 cells, respectively. DVR-01 shows antiviral activity against drug-resistant HBV mutants with EC50s of 2.403-3.273 μM. DVR-01 can be used for the research of HBV infection and related diseases. |
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| DC72295 |
SpdSyn binder-1
Featured
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SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria. |
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| DC72304 |
MMRi62
Featured
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MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12. |
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| DC72326 |
Tabernanthalog
Featured
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Tabernanthalog is a water-soluble, non-hallucinogenic and non-toxic analogue of ibogaine. Tabernanthalog is a 5-HT2A agonist. Tabernanthalog is found to promote structural neural plasticity, reduce alcohol- and heroin-seeking behaviour, and produce antidepressant-like effects in rodents. |
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| DC72329 |
Upidosin
Featured
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Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction. |
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| DC72335 |
JNJ10191584
Featured
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JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively. |
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| DC72339 |
PF-07258669
Featured
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PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa. |
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| DC72349 |
CP-447697
Featured
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CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation. |
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| DC72365 |
BAY-390
Featured
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BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. |
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| DC72367 |
TDI-11861
Featured
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TDI-11861 is second-generation soluble Adenylyl Cyclase (sAC, ADCY10) inhibitor with slow dissociation rates. TDI-11861 inhibits sAC cellular with an IC50 value of 5.5 nM. |
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| DC72415 |
Oct4 inducer-1
Featured
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Oct4 inducer-1 (compound OAC-3) is a potent Oct4 activator. Oct4 inducer-1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. Oct4 inducer-1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time. |
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| DC72426 |
DSPE-SPDP
Featured
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DSPE-SPDP is a phospholipid molecule. DSPE-SPDP can orient itself to form lipid bilayer in water. DSPE-SPDP can be used for the research of various biochemical. |
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| DC72429 |
DSPE-glutaric acid
Featured
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DSPE-glutaric acid is a lipid. DSPE-glutaric acid can be used for the research of various biochemical. |
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| DC72430 |
DSPE-Mal
Featured
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DSPE-MAL is a thiol reactive a phospholipid compound. DSPE-MAL has two saturated fatty acids and can self-assemble in water to form lipid bilayer. DSPE-MAL can be used to prepare liposomes as drug nanocarrier. |
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| DC72432 |
DSPE-N3
Featured
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DSPE-N3 is a lipid. DSPE-N3 can be used for the research of various biochemical. |
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| DC72451 |
PBT 1033
Featured
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PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria. |
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| DC72454 |
ZINC00640089
Featured
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ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC). |
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| DC72460 |
SRI 6409-94
Featured
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SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity. |
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| DC72483 |
CFT7455
Featured
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CFT7455 is an orally active zinc finger transcription factors (IKZF1) (Ikaros) and IKZF3 (Aiolos) degrader. It binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM). It is used in the treatment of multiple myeloma & non-Hodgkin’s lymphoma. |
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| DC72485 |
HBC620
Featured
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HBC620 is an analogue of HBC which is a GFP fluorophore-like synthetic dye that is nonfluorescent in solution, but strongly fluoresces upon forming tight complex with Pepper RNA aptamer. HBC-Pepper complex can be used to visualize RNA dynamics in live cells. |
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| DC72487 |
KCC-07
Featured
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KCC-07 is a potent, selective and brain-penetrant inhibitor of MBD2 (methyl-CpG-binding domain protein 2) with anticancer activity. It prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. |
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