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MPTP (hydrochloride)

  Cat. No.:  DC9542   Featured
Chemical Structure
23007-85-4
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More than 5000 active chemicals with high quality for research!
Field of application
MPTP HCl induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 23007-85-4
Chemical Name: MPTP
Synonyms: MPTP
SMILES: CN1CCC(C2=CC=CC=C2)=CC1.Cl
Formula: C12H16ClN
M.Wt: 209.7151
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease.
In Vivo: The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat[2]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[4].
In Vitro: Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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