Cat. No. | Product name | CAS No. |
DC8377 |
CC-115
Featured
CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. |
1228013-15-7 |
DC10146 |
CC-122(Avadomide)
Featured
CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL. |
1015474-32-4 |
DC8497 |
CC-223
Featured
CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM). |
1228013-30-6 |
DC7096 |
CC-401
Featured
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. |
1438391-30-0 |
DC20866 |
CC-671
Featured
CC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively. |
1618658-88-0 |
DC11588 |
CC-885
Featured
CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1. |
1010100-07-8 |
DC12590 |
CCB 02
Featured
CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay, selectively binds at the CPAP binding site of tubulin. |
2100864-57-9 |
DC7319 |
CCDC(TGR5-Receptor-Agonist)
Featured
CCDC is a otent, selective TGR5 G-protein coupled receptor agonist (pEC50 = 6.8). |
1197300-24-5 |
DC9757 |
CCF642
Featured
CCF642 is a novel protein disulfide isomerases (PDI) inhibitor. |
346640-08-2 |
DC7979 |
CCG1423
Featured
CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. |
285986-88-1 |
DC10535 |
CCG-203971
Featured
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50 = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. |
1443437-74-8 |
DC11302 |
CCG215022
Featured
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, GRK5 and GRK1, respectively. |
1813527-81-9 |
DC22819 |
CCG-50014
Featured
CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. |
883050-24-6 |
DC26030 |
CCMI
Featured
CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). |
917837-54-8 |
DC12302 |
CCR2 antagonist 3
Featured
CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist. |
1380100-86-6 |
DC7803 |
CCT007093
Featured
CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
176957-55-4 |
DC10005 |
CCT196969
Featured
CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. |
1163719-56-9 |
DC10911 |
CCT241736
Featured
CCT241736 is a novel, orally bioavailable Dual FLT3-Aurora Kinase Inhibitor. |
1402709-93-6 |
DC8324 |
CCT244747
Featured
CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. |
1404095-34-6 |
DC10498 |
CCT251236
Featured
CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. |
1693731-40-6 |
DC9968 |
CCT251545
Featured
CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. |
1661839-45-7 |
DC11679 |
CCT-367766
Featured
CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1]. |
2229856-58-8 |