| DC20097 |
Kojic acid
Featured
|
Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent. |
|
| DC12108 |
KP-457
Featured
|
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and 5050s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MM |
|
| DC7181 |
KPT-276
Featured
|
KPT-276, analog of KPT-185, is an orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1. |
|
| DC7067 |
KPT-330(Selinexor)
Featured
|
KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. |
|
| DC11276 |
KPT-6566
Featured
|
KPT-6566 is a covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. |
|
| DC10041 |
KR-33494
Featured
|
KR-33494 is a fluorescent-tagged and biotin-tagged probe of a potent inhibitor for Fas-mediated cell death (FAF1), KR-33493. |
|
| DC7793 |
K RAS INHIBITOR-12
Featured
|
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
-inhibitor-12-chemical-structure.gif)
|
| DC7722 |
K-RAS inhibitor 9
Featured
|
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
|
| DC9906 |
K-Ras-IN-1
Featured
|
K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. |
|
| DC8127 |
KRCA-0008
Featured
|
KRCA-0008 is a potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). |
|
| DC9963 |
Kribb11
Featured
|
KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). |
|
| DC11375 |
KRIBB3
Featured
|
KRIBB3 is an Hsp27 and microtubule inhibitor that inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner. |
|
| DC10454 |
KRN633
Featured
|
KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. |
|
| DC9256 |
KS176
Featured
|
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. |
|
| DC21205 |
KT-109
Featured
|
KT-109 is a potent, selective inhibitor of DAGLβ with IC50 of 42 nM, displays about 60-fold selectivity over DAGLα. |
|
| DC23732 |
KT-5823
Featured
|
KT-5823 is a potent, highly specific PKG (cGMP-dependent protein kinase) inhibitor with Ki of 0.234 uM, displays little to no activity for MLCK, cAPK, and PKC. |
|
| DC3113 |
KU-0060648
Featured
|
KU 0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. |
|
| DC1067 |
KU-55933
Featured
|
KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively. |
|
| DC7448 |
KU-60019
Featured
|
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM. |
|
| DC8522 |
KW-2449
Featured
|
KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. |
|
| DC9860 |
KW-2449 Hydrochloride
Featured
|
KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. |
|
| DC7449 |
KW-2478
Featured
|
KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2 |
|
| DC7582 |
KX1-004
Featured
|
KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL. |
|
| DC8023 |
KX2-391
Featured
|
KX2-391, the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. |
|
| DC1032 |
KY02111
Featured
|
KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting WNT signaling. |
|
| DC22132 |
KY-05009
Featured
|
KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM. |
|
| DC10556 |
KY1220
Featured
|
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. |
|
| DC9880 |
KYA1797K
Featured
|
KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). |
|
| DC10669 |
KYP-2047
Featured
|
KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). |
|
| DC12484 |
KZR-616
Featured
|
KZR-616 (KZR616) is a potent, selective dual immunoproteasome subunit LMP7/LMP2 inhibitor with IC50 of 39 nM/139 nM, weakly inhibits β5, MECL-1 and no acitivty against β1 subunit. |
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