| DC12191 |
JQ-35-(S)
Featured
|
JQ-35, (S)- is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity. |
|
| DC11421 |
JQEZ5
Featured
|
JQEZ5 is a novel and potent EZH2 inhibitor. |
|
| DC12422 |
JSH-150
Featured
|
JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM). |
|
| DC7741 |
JSH-23
Featured
|
JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM. |
|
| DC10607 |
JTE-013
Featured
|
JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
|
| DC26081 |
JTE-852
Featured
|
JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively. |
|
| DC7169 |
JW55
Featured
|
JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively. |
|
| DC8352 |
JZL-195
Featured
|
JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively). |
|
| DC5143 |
JZL184
Featured
|
JZL184 is a strong and selective inhibitor of Monoglyceride Lipase |
|
| DC9272 |
K 858
Featured
|
K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics. |
|
| DC7742 |
K02288
Featured
|
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. |
|
| DC9286 |
K03861
Featured
|
K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. |
|
| DC7774 |
Ripasudil(K-115)
Featured
|
K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension. |
|
| DC9625 |
K145 (hydrochloride)
Featured
|
K145 is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
IC50 value: 4.3 uM. |
|
| DC21196 |
K-604
Featured
|
K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2. |
|
| DC23031 |
Astragalin
Featured
|
Kaempferol-3-glucoside is an orally bioavailable flavonoid that has been isolated from the leaves of D. kaki and R. agrestis and has anti-inflammatory activity. |
|
| DC10495 |
KAI407
Featured
|
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. |
|
| DC21199 |
KAR-5585
Featured
|
KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice. |
|
| DC7669 |
Kartogenin (KGN)
Featured
|
Kartogenin(KGN) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation(EC50=100 nM) and binds to filamin A. |
|
| DC8084 |
kb NB 142-70
Featured
|
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. |
|
| DC7717 |
kb-NB77-78
Featured
|
kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor). |
|
| DC7832 |
KB-R7943 mesylate
Featured
|
KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 mM). |
|
| DC10852 |
KBU2046
Featured
|
KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs. |
|
| DC8447 |
KC7F2
Featured
|
KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study. |
|
| DC10586 |
KDM4D-IN-1
Featured
|
KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. |
|
| DC23376 |
KDM5-C70
Featured
|
KDM5-C70 is the cell-permeable derivative of KDM5-C49, potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively. |
|
| DC10285 |
KDM5-IN-1
Featured
|
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. |
|
| DC20226 |
KDOAM25（GTPL8576）
Featured
|
KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. |
|
| DC10746 |
KDU691
Featured
|
KDU691 is a PI4K inhibitor. |
|
| DC11627 |
KEA1-97
Featured
|
KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
|
