| DC10391 |
EBI2 inhibitor GS682753A |
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. |
|
| DC10233 |
Guanfacine Hydrochloride |
Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect. |
|
| DC9819 |
Guanoclor
Featured
|
Guanoclor is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes. |
|
| DC9458 |
GW-1100 |
GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.
|
|
| DC8266 |
GW-627368X
Featured
|
GW 627368X is a selective prostanoid EP4 receptor competitive antagonist with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays). |
|
| DC12266 |
H4 Receptor antagonist 1 |
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. |
|
| DC10935 |
HAMI3379 |
HAMI3379 (HAMI-3379) is a potent and selective antagonist of cysteinyl leukotriene 2 (CysLT(2)) receptor, inhibits LTD4- and LTC4-induced intracellular calcium mobilization withIC50 of 3.8 nM and 4.4 nM respectively. |
|
| DC12493 |
HT-2157(SNAP37889)
Featured
|
HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3). |
|
| DC11328 |
Hydroxyzine |
Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM). |
|
| DC7020 |
Ibutamoren mesylate
Featured
|
Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue. |
|
| DC3115 |
ICI-118551
Featured
|
ICI-118,551 is a selective beta-2 (β2) adrenergic receptor antagonist.ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. |
|
| DCAPI1055 |
Iloperidone (Fanapt) |
Iloperidone (Fanapt) |
|
| DC9389 |
INCB3344 |
INCB3344 is a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor; inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).
|
|
| DC7429 |
INCB 8761
Featured
|
INCB8761(PF-4136309) is a potent, Selective, and orally bioavailable CCR2 antagonist. |
|
| DCAPI1701 |
Indacaterol Maleate |
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36. |
|
| DC8914 |
Indacaterol
Featured
|
Indacaterol is a potent, orally administered ultra-long-acting β2 adrenergic receptor (ADRB2) agonist, widely recognized for its therapeutic potential in respiratory and cardiovascular conditions. By selectively activating ADRB2, indacaterol not only enhances bronchodilation but also exhibits a unique mechanism of action by inhibiting NF-κB activity in a β-arrestin2-dependent manner. This dual functionality helps mitigate lung inflammation, prevent further pulmonary damage, and improve lung function in patients with chronic obstructive pulmonary disease (COPD). Beyond its respiratory applications, indacaterol has also emerged as a valuable tool in cardiovascular disease research, offering insights into its broader therapeutic effects. Its multifaceted pharmacological profile positions indacaterol as a promising candidate for addressing complex disease mechanisms and advancing treatment strategies in both respiratory and cardiovascular fields. |
|
| DC7197 |
ML 161
Featured
|
Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation. |
|
| DC8996 |
Isoprenaline HCl |
Isoprenaline Hydrochloride is a non-selective beta-adrenergic agonist and structurally similar to adrenaline. |
|
| DCAPI1080 |
Istradefylline (KW-6002)
Featured
|
Istradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson's disease. |
|
| DC8304 |
Isoxazole 9(ISX9)
Featured
|
ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. |
|
| DC10283 |
IT1t dihydrochloride
Featured
|
IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
|
| DC10306 |
IT1t |
IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
|
| DC10095 |
JD5037
Featured
|
JD5037 is an inverse agonist of peripheral cannabinoid 1 (CB1) receptors (Ki = 0.35 nM). |
|
| DC9524 |
JDTic (dihydrochloride) |
JDTic 2Hcl is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors. |
|
| DC10971 |
JMS-17-2
Featured
|
JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM). |
|
| DC7843 |
JNJ 42153605
Featured
|
JNJ 42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. |
|
| DC12374 |
JNJ-10229570
Featured
|
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively. |
|
| DC8140 |
JNJ31020028
Featured
|
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. |
|
| DC12166 |
JNJ-5207852
Featured
|
JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively. |
|
| DC9271 |
JNJ-63533054
Featured
|
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. |
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