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Inhibitors & Agonists

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Cat. No. Product Name Field of Application Chemical Structure
DC11005 AGN192836 AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
DC3171 Agomelatine Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
DC20304 AGPS-IN-1a AGPS-IN-1a is a potent inhibitor of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS), selectively lowers ether lipid levels in several types of human cancer cells and impairs their cellular survival and migration..
DC12535 AgrA inhibitor F19 AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription.
DC7632 AHAS inhibitor(BTB06584) Featured AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
DC8735 AHU-377 hemicalcium salt Featured AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM.
DC8734 AHU-377(Sacubitril) AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM.
DC20305 AI-10-104 Featured AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays.
DC9402 Letermovir(AIC-246) Featured AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
DC23900 AICAR phosphate Featured AICAR phosphate (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.
DC9330 AIM-100 Featured AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM IC50 value: 24 nM [3] Target: Ack1 Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 ph
DC12402 AJM300 AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis..
DC23660 AK106-001616(AK 106-001616) AK106-001616 (AK 106-001616) is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) with IC50 of 3.8 nM (human cPLA2 enzyme).
DC21991 AK306 AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
DC7540 SIRT2 Inhibitor II, AK-7 Featured AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).
DC23789 AK778 Featured AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix. .
DC20649 AKB-9778 Featured AKB-9778 is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP) with IC50 of 17 pM.
DC12158 AKOS B018304 Featured AKOS B018304 is an arylalkylidene derivative, with polar substitution at para-position.
DC10941 AKR1C3 inhibitor KV-37 AKR1C3 inhibitor KV-37 is a potent, isoform selective and metabolically stable inhibitor of Aldo-keto reductase 1C3 (AKR1C3) with IC50 of 66 nM, displays 109-fold selectivity over AKR1C2.
DC8458 Akt Inhibitor VIII Featured Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).
DC8695 Akt1 and Akt2-IN-1 Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.
DC9677 AL 082D06(D-06) Featured AL 082D06(D-06) is the first selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM, exhibits excellent selectivity against AR, PR, MR and ER(Ki > 10 uM).
DC20260 AL-335 Featured AL-335 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase with IE50 values as low as 70 nM. AL-335 is potentially useful for the Treatment of Hepatitis C Infection. AL-335 demonstrated high levels of the nucleoside triphosphate in vitro in primary human hepatocytes and Huh-7 cells as well as in dog liver following a single oral dose. AL-335 was selected for the clinical development where it showed promising results in phase 1 and 2 trials.
DC21111 AL-9 AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM.
DC20652 ALB-127158 ALB-127158 is a potent (IC50=7 nM), selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) for treatment of obesity..
DC10780 ALB-127158(a) Featured ALB-127158A, also known as ALB-127158(a), is a MCH1 antagonist for the treatment of obesity.
DCAPI1243 Albendazole(Albenza) Albendazole(Albenza)
DC20174 Albiglutide Featured Albiglutide is a glucagon-like peptide-1 agonist (GLP-1 agonist).
DCAPI1467 Alcaftadine Alcaftadine
DC8723 Alda-1 Featured Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).

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