DC11005 |
AGN192836 |
AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively. |
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DC3171 |
Agomelatine |
Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
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DC20304 |
AGPS-IN-1a |
AGPS-IN-1a is a potent inhibitor of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS), selectively lowers ether lipid levels in several types of human cancer cells and impairs their cellular survival and migration.. |
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DC12535 |
AgrA inhibitor F19 |
AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription. |
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DC7632 |
AHAS inhibitor(BTB06584)
Featured
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AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). |
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DC8735 |
AHU-377 hemicalcium salt
Featured
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AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. |
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DC8734 |
AHU-377(Sacubitril) |
AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. |
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DC20305 |
AI-10-104
Featured
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AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays. |
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DC9402 |
Letermovir(AIC-246)
Featured
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AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. |
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DC23900 |
AICAR phosphate
Featured
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AICAR phosphate (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes. |
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DC9330 |
AIM-100
Featured
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AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM
IC50 value: 24 nM [3]
Target: Ack1
Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 ph |
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DC12402 |
AJM300 |
AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.. |
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DC23660 |
AK106-001616(AK 106-001616) |
AK106-001616 (AK 106-001616) is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) with IC50 of 3.8 nM (human cPLA2 enzyme). |
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DC21991 |
AK306 |
AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM. |
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DC7540 |
SIRT2 Inhibitor II, AK-7
Featured
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AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). |
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DC23789 |
AK778
Featured
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AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix. . |
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DC20649 |
AKB-9778
Featured
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AKB-9778 is a potent, selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP) with IC50 of 17 pM. |
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DC12158 |
AKOS B018304
Featured
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AKOS B018304 is an arylalkylidene derivative, with polar substitution at para-position. |
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DC10941 |
AKR1C3 inhibitor KV-37 |
AKR1C3 inhibitor KV-37 is a potent, isoform selective and metabolically stable inhibitor of Aldo-keto reductase 1C3 (AKR1C3) with IC50 of 66 nM, displays 109-fold selectivity over AKR1C2. |
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DC8458 |
Akt Inhibitor VIII
Featured
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Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). |
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DC8695 |
Akt1 and Akt2-IN-1 |
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. |
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DC9677 |
AL 082D06(D-06)
Featured
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AL 082D06(D-06) is the first selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM, exhibits excellent selectivity against AR, PR, MR and ER(Ki > 10 uM). |
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DC20260 |
AL-335
Featured
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AL-335 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase with IE50 values as low as 70 nM. AL-335 is potentially useful for the Treatment of Hepatitis C Infection. AL-335 demonstrated high levels of the nucleoside triphosphate in vitro in primary human hepatocytes and Huh-7 cells as well as in dog liver following a single oral dose. AL-335 was selected for the clinical development where it showed promising results in phase 1 and 2 trials. |
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DC21111 |
AL-9 |
AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM. |
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DC20652 |
ALB-127158 |
ALB-127158 is a potent (IC50=7 nM), selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) for treatment of obesity.. |
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DC10780 |
ALB-127158(a)
Featured
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ALB-127158A, also known as ALB-127158(a), is a MCH1 antagonist for the treatment of obesity. |
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DCAPI1243 |
Albendazole(Albenza) |
Albendazole(Albenza) |
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DC20174 |
Albiglutide
Featured
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Albiglutide is a glucagon-like peptide-1 agonist (GLP-1 agonist). |
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DCAPI1467 |
Alcaftadine |
Alcaftadine |
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DC8723 |
Alda-1
Featured
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Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). |
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