| DC7049 |
AdipoRon
Featured
|
AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). |
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| DC7050 |
ADL5859 HCl
Featured
|
ADL5859 agonizes δ-opioid receptor with a 1000-fold selectivity than µ- or κ-opioid receptor with Ki of 32 nM and 37 nM, respectively.ADL5859 displays weak inhibitory activity at the hERG channel with an IC50 of 78 μM. The EC50 of ADL5859 against δ opioid |
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| DC20644 |
ADM 12 |
ADM 12 (ADM_12. |
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| DC9324 |
Adoprazine |
Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
|
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| DC12115 |
Adrenomedullin (AM) (1-52), human TFA (Human adrenomedullin-(1-52)-NH2 (TFA)) |
Adrenomedullin (AM) (1-52), human (TFA) affects cell proliferation and angiogenesis in cancer. |
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| DC20645 |
ADT-094 |
ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively. |
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| DC10577 |
ADT-OH
Featured
|
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. |
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| DC21281 |
ADU-S100
Featured
|
ADU-S100 (MIW815) is a synthetic cyclic dinucleotide agonist of STING, elicits potent and durable anti-tumor immunity when administered IT in pre-clinical syngeneic tumor models.. |
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| DC11097 |
ADX-102 (Reproxalap;NS-2)
Featured
|
ADX-102 (Reproxalap, NS-2) is a novel small molecule immunomodulator that covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal, which have been shown to mediate inflammatory pain; DX-102 is a promising agent for the treatment of dry eye disease. |
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| DC8087 |
ADX 47273
Featured
|
ADX-47273 is a novel, potent and selective metabotropic glutamate receptor 5 allosteric modulator with an EC50 of 170 nM. |
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| DC10465 |
ADX-88178
Featured
|
ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor. |
|
| DC7703 |
AEBSF-hydrochloride
Featured
|
AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor. |
|
| DC5113 |
AEE-788 (NVP-AEE788)
Featured
|
AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2. |
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| DC21988 |
AER-271
Featured
|
AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility. |
|
| DC21989 |
AES-135
Featured
|
AES-135 (AES135) is a novel HDAC inhibitor that biochemically inhibits HDACs 3, 6, 8 and 11 with IC50 values of 190-1100 nM. |
|
| DC8355 |
Adjudin (AF-2364)
Featured
|
AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague–Dawley rats. |
|
| DC7783 |
AF-353(Ro-4)
Featured
|
AF-353 is a novel, orally bioavailable, highly potent and selective P2X3/P2X2/3 receptor antagonist. |
|
| DC23140 |
AF38469
Featured
|
AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM, shows no activity against the NTR1 receptor as well as a panel of targets known to bind acidic molecules (δ-Opioid, GPR40, PPARδ, EP1, Angiotensin AT1, Endothelin |
|
| DC12539 |
AF40431 |
AF40431 (AF-40431) is the first reported small-molecule ligand of the VPS10P family sorting receptor Sortilin with IC50 of 4.4 uM, binds in the neurotensin-binding site of sortilin.. |
|
| DC11170 |
AF64394
Featured
|
AF64394 is a potent, selective GPR3 inverse agonist with pIC50 of 7.3, displays >100-fold selectivity over GPR6 and GPR12. |
|
| DC23642 |
AF-792 |
AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors. |
|
| DC3164 |
BIBW2992-MA2 (Afatinib dimaleate)
Featured
|
Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2. |
|
| DC20108 |
Afegostat D-Tartrate (D-Isofagomine (D-Tartrate); Isofagomine (D-Tartrate)) |
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity. |
|
| DC9026 |
Afloqualone |
Afloqualone is a agonist of GABA receptor . |
|
| DC10513 |
AFN-1252(Debio 1452)
Featured
|
AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. |
|
| DC9764 |
Afoxolaner
Featured
|
Afoxolaner is an isoxazoline that inhibits insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), blocking pre and post synaptic transfer of chloride ions across cell membranes. |
|
| DC10844 |
Aftin-4
Featured
|
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. |
|
| DC7994 |
Afuresertib HCl
Featured
|
Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM). |
|
| DC8411 |
Afuresertib
Featured
|
Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2. |
|
| DC10589 |
AG 1406
Featured
|
AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 . |
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