| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC8322 | Anacardic Acid Featured | Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively. |
|
| DC7804 | Anacetrapib(MK0859) Featured | Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3. |
|
| DC9429 | Anagliptin | Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9. |
|
| DC9580 | Anagrelide (hydrochloride) | Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis. |
|
| DC7357 | Anamorelin Featured | Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. |
|
| DCAPI1425 | Anastrozole Featured | Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition. |
|
| DC11649 | Jamaicin (AnCoA4) Featured | AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
|
| DC8122 | Andarine (GTX-007,S-4) Featured | GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity. |
|
| DC20085 | Androgen receptor modulators 1 | Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM. |
|
| DC12143 | Anemarrhenasaponin I | Anemarrhenasaponin I, a traditional Chinese medicine, is isolated from Anemarrhena asphodeloides Bunge. |
|
| DC12113 | Anemarsaponin E | Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity. |
|
| DC24123 | Angiotensin 1-7 | Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM. |
|
| DC9348 | Angiotensin II human | Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. |
|
| DC24109 | Anguizole | Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM. |
|
| DCAPI1490 | Anidulafungin Featured | Anidulafungin |
|
| DC8976 | Aniracetam | Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR. |
|
| DC10168 | Anle138b Featured | Anle138b is a novel oligomer modulator. |
|
| DC20670 | ANT431 Featured | ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
|
| DC20671 | ANT431 sodium | ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
|
| DC11088 | Fosmanogepix | antifungal. |
|
| DC23276 | Antimalarial compound 49c | Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM. |
|
| DC20308 | Antimycin A | Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over. |
|
| DC8959 | Antipyrine | Antipyrine is an analgesic and antipyretic agent |
|
| DC22094 | ANY1 | ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA). |
|
| DC10950 | AOH1160 | AOH1160 is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA). |
|
| DC11196 | AP14145 | AP14145 (AP-14145) is a potent, selective negative allosteric modulator of KCa2.2 and KCa2.3 with equal potency (IC50=1.1±0.3 uM). |
|
| DC20078 | AP1867 Featured | AP1867 is a synthetic FKBP12F36V-directed ligand. |
|
| DC22207 | AP1903 Featured | AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM. |
|
| DC8581 | AP219 | AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion. |
|
| DC1020 | Ponatinib (AP24534) Featured | AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
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