AOH1160|AOH-1160;AOH 1160

Cas No.:	2089314-57-6
Chemical Name:	N-(2-oxo-2-((2-phenoxyphenyl)amino)ethyl)-1-naphthamide
Synonyms:	AOH-1160;AOH 1160
SMILES:	C(C(NCC(=O)NC1=CC=CC=C1OC1=CC=CC=C1)=O)1=C2C(C=CC=C2)=CC=C1
Formula:	C₂₅H₂₀N₂O₃
M.Wt:	396.446
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AOH1160 is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA); selectively kills many types of cancer cells at below micromolar concentrations (mean GI50=330 nM) without causing significant toxicity to a broad range of non-malignant cells, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, and causes cell cycle arrest; suppresses tumor growth without causing significant side effects in mice, demostrates the potential as a broad-spectrum therapeutic agent for cancer treatment.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC10950	AOH1160	AOH1160 is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA).
DC10920	A12B4C3	A12B4C3 (hPNKP inhibitor A12B4C3) is a specific, noncompetitive inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase (hPNKP) with C50 of 60 nM, displays no inhibition of calcineurin and protein phosphatase-1 or APTX.