| DC7836 |
Doramapimod (BIRB-796)
Featured
|
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ. |
|
| DC5023 |
Birinapant (TL32711)
Featured
|
Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. |
|
| DC10863 |
Bis(tributylammonium) difluoromethylenediphosphonate
Featured
|
Bis(tributylammonium) difluoromethylenediphosphonate |
|
| DC10434 |
Bisantrene
Featured
|
Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases. |
|
| DC10504 |
BISF-3
Featured
|
BISF CAS 118511-97-0 |
|
| DC10052 |
Bisindolylmaleimide X(Ro 31-8425)
Featured
|
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). |
|
| DC8504 |
Bisindolylmaleimide X HCl
Featured
|
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). |
|
| DC20798 |
Bisperoxovanadium |
Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=3 |
|
| DC20212 |
Bisphenol A |
Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties. |
|
| DC21599 |
Bis-T-23 |
Bis-T-23 is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes. |
|
| DC11307 |
Bitertanol |
Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina. |
|
| DC8882 |
Bitopertin
Featured
|
Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM. |
|
| DC9616 |
BIX 02565
Featured
|
BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM.
|
|
| DC7374 |
BIX01294
Featured
|
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM. |
|
| DC5002 |
BIX02188 (BIX 02188）
Featured
|
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
|
| DC5003 |
BIX02189 (BIX 02189） |
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
|
| DC23383 |
Bizine |
Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively. |
|
| DC20739 |
BJE6-106 |
BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα). |
|
| DC22637 |
BKI1369
Featured
|
BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves. |
|
| DC5154 |
BKM120 (NVP-BKM120, Buparlisib)
Featured
|
BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. |
|
| DC23439 |
BL-1020 |
BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist. |
|
| DC11003 |
BL5923 |
BL5923 (BL-5923) is a potent, highly specific, orally available inhibitor of CCR1 with IC50 of 20.4 and 22.8 nM for human and mouse CCR1, resepctively. |
|
| DC20800 |
BL-918
Featured
|
BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells. |
|
| DC12391 |
BL-AD008
Featured
|
BL-AD008 (BL-AD 008) is a novel small molecule, dual-target activator targeting AMPK/ZIPK; demonstrates remarkable anti-proliferative activities toward cervical cancer cells and could induce apoptosis by death-receptor and mitochondrial pathways; also sho |
|
| DC20107 |
Blasticidin S hydrochloride |
Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. |
|
| DC4196 |
Bleomycin Sulfate
Featured
|
Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
|
| DC7087 |
Blonanserin(AD-5423) |
Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, atypical antipsychotic. |
|
| DC20801 |
BLT-1
Featured
|
BLT-1 is an irreversible Scavenger receptor class B member I (SR-BI) inhibitor that blocks SR-BI-mediated selective lipid uptake and bidirectional cholesterol flux with an IC50 of 50 nM; significantly inhibits baicalin-induced cholesterol efflux in THP-1 macrophages. |
|
| DC10530 |
BLU-285 (Avapritinib)
Featured
|
BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V. |
|
| DC10092 |
BLU554(Fisogatinib)
Featured
|
BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. |
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