AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors.

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.

Amcasertib(BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways, including Nanog, by targeting stemness kinases.

AMD3465 is a Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM).

Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.).

Amenamevir, also known as ASP2151, is a herpes virus helicase-primase inhibitor.

Ametantrone is a new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation.

AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.

AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

AMG 853 is novel a CRTH2 and DP Dual Antagonist.

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2.

AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell.

AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism.

AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).

AMG-1 is a potent inhibitor of human c-Met and RON with IC50 values of 4 and 9 nmol/L respectively.

AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly.

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.

AMG232 is a potent, selective and orally bioavailable inhibitor of MDM2−p53 interaction with IC50 value of 9.1 nM in EdU cells .

AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays.

AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC 50 of 4 nM.

AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met).

AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.

AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chro

AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.

AMG7703 (4-CMTB, AMG-7703) is an allosteric, selective agonist of FFAR2 (GPR43)..

AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM).

Amgen16 is a highly potent inhibitor of NF-κB inducing Kinase (NIK), example 294 in patent WO 2009158011 A1..

AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM).

AMI-1 is a PRMT and HIV-1 RT polymerase inhibitor.

Amicarbazone(BAY-MKH3586; BAY314666) is a potent inhibitor of photosynthetic electron transport via binding to the Qb domain of photosystem II (PSII); herbicide with a broad spectrum of weed control.

Amidopyrine is white crystalline substance used as an analgesic and antipyretic.

Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.

Aminocaproic acid (Amicar)is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM.

Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).

Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.

Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.

Amitriptyline is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain.

Amlodipine besylate is a long-acting calcium channel blocker.

Ammonium Glycyrrhizinate (AMGZ)

Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.

Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.

Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.

Amorolfine hydrochloride is a antifungal reagent.

Amoscanate(nithiocyamine) is an experimental anthelmintic agent of the arylisothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans,and is also highly active against hookworm

Amoxicillin sodium (Amox)

Ampalex (Ampakine CX516) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.

Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

AMPK activator 991 is an allosteric AMPK activator, activates non-phosphorylated Thr172 AMPK in vitro binds to α1β1γ1 and α2β1γ1 with Kd of 0.13 and 0.17 uM, respectively..

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle.

Ampkinone is a novel small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM).

AMPPD, 1,2-dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate.

Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively.

Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.

AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively.

Amrubicin(SM-5887) is a novel anthracycline derivative for treatment of bladder carcinoma.

Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.

amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).For the detailed information of TAC-101, the solubility of TAC-101 in water, the solubility of TAC-101 in DMSO, the solubility of TAC-101 in PBS buffer, the animal experiment (test) of TAC-101, the cell expriment (test) of TAC-101, the in vivo, in vitro and clinical trial test of TAC-101, the EC50, IC50,and Affinity of TAC-101, Please contact DC Chemicals..

Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively.

Amuvatinib hydrochloride (MP470 hydrochloride) is a multi-targeted receptor tyrosine kinases inhibitor, which inhibits c-Kit (D816V), c-Kit (D816H), c-Kit (V560G), c-Kit (V654A), PDGFRα (D842V), and PDGFRα (V561D) with IC50s of 950 nM, 10 nM, 34 nM, 127 n

AMXT-1501 (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination of with DFMO.

AMXT-1501 tetrahydrochloride (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination with DFMO.

AMZ30 is a potent, selective, covalent inhibitor of the serine hydrolase protein phosphatase methylesterase-1 (PME-1) with IC50 of 0.6 uM, >100-fold selectivity over other SHs.

An acetylcholinesterase (AChE) inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].

An active metabolite of the selective estrogen receptor modulator (SERM) tamoxifen.

An adenosine A1 receptor agonist (EC50= 8.2 nM)..

An agent for the treatment of nephropathic cystinosis and an antioxidant.

An alkaloid of Hydrastis canadensis used in many dietary supplements intended to enhance the immune system.

Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).

An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.

An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.

An amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.

An aminoglycoside antibiotic similar in structure to gentamicin B1.

An aminoglycoside antibiotic used in veterinary medicine..

An aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia. .

An analog of adenosine 5’-monophosphate that potently and selectively inhibits NEDD8-activating enzyme (NAE) with IC50 of 4.7 nM.

An analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.

An analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic..

An analogue of deoxyspergualin that has immunostimulating activity, promotes resistance to Candida albicans infection in mice..

An angiotensin II analog that is an agonist of AT1 angiotensin receptor..

An anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.

An anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.

An anthelmintic that has antibacterial and anthelmintic properties along with algaecide activity.

An anthelmintic that has antibacterial and anthelmintic properties along with algaecide activity.

An antiaggressive agent that acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor..

An antiaggressive agent that acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor..

An antibiotic that inhibits eukaryotic protein synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

An antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis..

An antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis..

An antibiotic used to treat a number of bacterial infections..

An anticancer phytochemical commonly found in black cumin.

An anticestodal agent, fungicide, germicide, and antimicrobial agent.

An antifungal agent that works by altering the permeability of the fungal cell wall.

An antifungal antibiotic that inhibits fatty acid synthase (FASN), also blocks cellular proliferation of KRAS-associated lung cancer cells.

An anti-infective, anti-bacterial agent.

An anti-inflammation agent..

An anti-inflammatory agent used in the treatment of osteoarthritis.

An antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites.

Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine.

An antimicrobial agent used as a substitute for chlorophenols

MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.

An antiprotozoal, antirheumatic and intrapleural sclerosing agent.

An antipsychotic agent with serotonin-S2 and dopamine-D2 antagonistic properties.

An antipsychotic agent with serotonin-S2 and dopamine-D2 antagonistic properties.

An antitrypansomal drug that also possesses antitumor activity.

An antiviral compound that inhibits attachment to cells, inhibits human rhinovirus type 14 (HRV14) replication..

An E3 ligase ligand-linker conjugate for PROTAC.

LE135 is a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.

An efficient prodrug of ampicillin with enhanced absorption and decreased side effects..

An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.

An enantiomer of Ibuprofen that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form.

An endogenous DHA metabolite that promotes neurite growth, synaptogenesis, and synaptic function both in vitro and in vivo.

Iperoxo is a superagonist of the muscarinic acetylcholine receptors and an OxotremorineM analog.

An imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.

An imidazolinone herbicide that effectively controls a broad spectrum of weed species..

An immunoactive peptide that has been shown to inhibit cell proliferation and induce apoptosis in human leukemia, non-small cell lung cancer, melanoma, and other human cancers.

Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.

IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

An impurity of Roflumilast, which is a selective and long-acting inhibitor of PDE-4 with IC50 value of 0.8 nM..

An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro.

An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM.

An inhibitor of aldose reductase with IC50 of 28.9 pM.

An inhibitor of histone demethylase..

An inhibitor of LPS-induced TNFαrelease.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects.

An inhibitor of the IMP-selective cytosolic 5'-nucleotidase (IC50=2-6 mM).

An insecticide agent that is approved for application on high-value crops such as grapes, tomatoes and other vegetables..

An insecticide agent..

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.

An irreversible local anesthetic.

An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.

PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively).

An non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B1-405.

Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.

An oral glucocorticoid agonist for the treatment of rheumatoid arthritis..

An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo..

An orally active anabolic-androgenic steroid and a 19-nortestosterone derivative that has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR..

An orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo.

An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.

An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI.

An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM.

An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM.

An orally active, second-generation steroid sulfatase inhibitor with IC50 of 0.5 nM.

An orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycopro

An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy.

An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM.

An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.

An orally available, potent and selective ileal bile acid transporter (IBAT) inhibitor for the treatment of constipation..

An orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities.

An orally-active, CNS permeable benzoxaborole antiprotozoal agent.

An organophosphate insecticide agent..

An organophosphorus anthelmintic used against nematodes of the abomasum and small intestine in ruminants. .

An oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo..

An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3.

An α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 29 nM for rat recombinant eN.

AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM.

AN-2690(Tavaborole), an antifungal agent with activity against Trichophyton species, in a topical solution formulation, for the potential treatment of onychomycosis.

AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.

AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.

AN3365 is a first-in-class antibiotic that demonstrates potent activity across a wide spectrum of Gram-negative bacteria, including those resistant to many other antibiotics.

ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.

ANA975 is an oral prodrug of the TLR-7 agonist Isatoribine (ANA245.

Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively.

Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.

Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.

Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.

Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia.

Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition.

AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.

GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity.

Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM.

Anemarrhenasaponin I, a traditional Chinese medicine, is isolated from Anemarrhena asphodeloides Bunge.

Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity.

Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM.

Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM.

Anidulafungin

Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.

Anle138b is a novel oligomer modulator.

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).

ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).

antifungal.

Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.

Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over.

Antipyrine is an analgesic and antipyretic agent

ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA).

AOH1160 is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA).

AP14145 (AP-14145) is a potent, selective negative allosteric modulator of KCa2.2 and KCa2.3 with equal potency (IC50=1.1±0.3 uM).

AP1867 is a synthetic FKBP12F36V-directed ligand.

AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM.

AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.

AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

ALK-IN-1 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.

APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.