| DC23558 |
(+)-NFPS |
A potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS. |
|
| DC11616 |
KUNG94 |
A potent, selective Grp94 inhibitor with IC50 of 8 nM. |
|
| DC11619 |
KUNG29 |
A potent, selective Grp94 inhibitor with Kd of 0.2 uM. |
|
| DC11618 |
KUNG38 |
A potent, selective Grp94 inhibitor with Kd of 0.44 uM. |
|
| DC11617 |
PU-H54
Featured
|
PU-H54 is potent, selective Grp94 inhibitor. |
|
| DC20400 |
HDAC1,2-IN-2 |
A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively. |
|
| DC11597 |
SB-429201 |
A potent, selective HDAC1 inhibitor with IC50 of 1.5 uM. |
|
| DC21373 |
HDAC6 inhibitor NCT-14b |
A potent, selective HDAC6 inhibitor with IC50 of 84 nM, with IC50s of >3.5 uM for the other HDAC isoforms.. |
|
| DC21461 |
PD-118057 |
A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells. |
|
| DC22946 |
ML-T531
Featured
|
ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM. |
|
| DC22990 |
HIF1-IN-2 |
A potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB. |
|
| DC25054 |
Gambogic amide |
A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM. |
|
| DC22966 |
ABH hydrochloride
Featured
|
A potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase. |
|
| DC11857 |
BAY-8040 (R)
Featured
|
Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension. |
|
| DC22454 |
IMPDH2-IN-5 |
A potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with IC50 of 620 nM (inhibition of NO production). |
|
| DC20345 |
CLK inhibitor 2 |
A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively. |
|
| DC11644 |
Pitstop 1 |
A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation). |
|
| DC11700 |
Chalcone 4 hydrate |
A potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM. |
|
| DC22897 |
KRH-1636 |
A potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5. |
|
| DC22847 |
L-870810 |
A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties. |
|
| DC11706 |
R-10015
Featured
|
A potent, selective inhibitor of human LIMK1 with IC50 of 38 nM . |
|
| DC23189 |
CL-82198
Featured
|
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. |
|
| DC22658 |
Windorphen |
A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM). |
|
| DC22625 |
Rolipram
Featured
|
A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
|
| DC23910 |
Microcystin-LR |
A potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
|
| DC11967 |
PF-06649298 |
A potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.41 uM. |
|
| DC22754 |
SKA-111 |
A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM. |
|
| DC23551 |
PF-05388169 |
A potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM). |
|
| DC23550 |
PF-05387252 |
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
|
| DC11507 |
CLP257
Featured
|
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM; displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors; restores impaired Cl(-) transport i |
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