BAY-8040|HNE inhibitor|CAS 1194453-23-0|DC Chemicals

Cas No.:	1194453-23-0
Chemical Name:	(R)-4-(7-methyl-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyridazin-4-yl)benzonitrile
Synonyms:	BAY 8040;BAY8040
SMILES:	C(C1C=CC([C@@H]2NC(=O)N(C3C=C(C(F)(F)F)C=CC=3)C3=C2C(NN(C3)C)=O)=CC=1)#N
Formula:	C₂₁H₁₆F₃N₅O₂
M.Wt:	427.379
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. von Nussbaum F, et al. ChemMedChem. 2016 Jan 19;11(2):199-206.

Description:

Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC46984	Lonodelestat	Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE).
DC11858	BAY-678	BAY-678 is a cell-permeable inhibitor of human neutrophil elastase (HNE).
DC11857	BAY-8040 (R)	Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.

BAY-8040 (R)