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| Cas No.: | 2097938-51-5 |
| Chemical Name: | Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl) piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate |
| Synonyms: | R 10015;R10015 |
| SMILES: | C(C1CCN(C2N=CN=C3NC=C(Cl)C3=2)CC1)1=NC2=CC(C(OC)=O)=CC=C2N1 |
| Formula: | C20H19ClN6O2 |
| M.Wt: | 410.86 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1[1]. |
| Target: | human LIMK1:38 nM (IC50) |
| In Vivo: | R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections[1]. Animal Model: 6-8 weeks female C3H/HeN mice[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection Result: Displayed none indication of toxicity. |
| In Vitro: | R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells[1]. R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release[1]. R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) [1]. Western Blot Analysis[1] Cell Line: CEM-SS T cells Concentration: 100 μM Incubation Time: 0 hour,0.5 hour,1 hour,2 hours,4 hours Result: Inhibited cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells. |
| References: | [1]. Yi F, et al. Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J Virol. 2017 Jun 9;91(13). pii: e02418-16. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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