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NS13001

  Cat. No.:  DC22753   Featured
Chemical Structure
1063331-94-1
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1063331-94-1
Chemical Name: N-(4-chlorophenyl)-2-(3,5-dimethyl-1h-pyrazol-1-yl)-9-methyl-9h-purin-6-amine
Synonyms: N-(4-chlorophenyl)-2-(3,5-dimethyl-1h-pyrazol-1-yl)-9-methyl-9h-purin-6-amine;NS13001;N-(4-chlorophenyl)-2-(3,5-diMethyl-1H-pyrazol-1-yl)-9-Methyl-9H-purin-6-aMine
SMILES: ClC1=CC=C(NC2N=C(N3N=C(C)C=C3C)N=C3N(C=NC=23)C)C=C1
Formula: C17H16ClN7
M.Wt: 353.808840751648
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias[1].
Target: EC50: 1.8 μM (SK2), 0.14 μM (SK3)[1]
References: [1]. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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