Cationic/Ionizable Lipids

As one of the major supplier in market, DC Chemicals provide more than 500 novel cationic ionizable lipids with wide range of diverse chemical structures for RNA delivery.

Cationic ionizable lipids play a major role in the LNP formulation and its ability to transfect target cells with its cargo. The ionizable lipids are used to complex negatively charged nucleic acid cargo. The mRNA-cationic lipid complex fuses with the cell membrane and is then delivered into the cytosol. To be able to play these roles efficiently, a cationic ionizable lipid must be engineered with a suitable apparent acid dissociation constant (pKa). The apparent pKa of a cationic ionizable lipid is the likely pKa at the LNP surface. Currently, the cationic ionizable lipids in FDA-approved therapeutics all have an apparent pKa between 6-7. This is crucial for the cationic ionizable lipid to maintain a neutral charge while in systemic circulation (pH above the pKa of the lipid, pH ~7.5), as well as its ability to become positively charged in the endosome (pH ~6.5) and facilitate membrane fusion and subsequent cytosolic release.

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Cat. No.	Product Name	Field of Application
DC82025	306-O12B-3 Featured	306-O12B-3 is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of antisense oligonucleotides (ASOs). LNPs containing 306-O12B-3 localize to the liver after intravenous administration in mice. LNPs containing 306-O12B-3 in combination with other lipids encapsulating ASOs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) decrease hepatic PCSK9 expression in mice. Intravenous administration of LNPs containing 306-O12B-3 and the cationic lipidoid NT1-O14B encapsulating ASOs against tau decreases tau expression and levels in mouse brain.
DC82101	AA3-DLin Featured	AA3-DLin is an ionizable cationic amino lipid (pKa = 5.8) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.LNPs containing AA3-DLin and encapsulating mRNA for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein induce immunogenicity in mice.
DC82102	PPZ-A10 Featured	PPZ-A10 is an ionizable cationic lipid.It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo. Intraperitoneal administration of LNPs containing PPZ-A10 and encapsulating an mRNA reporter preferentially accumulates in hepatic Kupffer cells and splenic macrophages in mice.
DC82105	93-O17O Featured	93-O17O is a chalcogen-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing 93-O17O localize to the spleen after intravenous injection into mice.LNPs containing 93-O17O have been used for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice and for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens.
DC82209	Lipid 10a-26 Featured	LIPID-10a-26 is an analogue of ALC-0315 with the head adjusted to imidazole. It is a novel cationic ionizable Lipid for RNA delivery.
DC82115	BAMP-TK-12	BAMP-TK-12 is ROS‐degradable lipid used for gene/RNA delivery.
DC82119	113-O16B Featured	113-O16B is a disulfide bond-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA.
DC82125	lipid 14 Featured	LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc mRNA). While both lipid 274 LNP RBD-hFc mRNA and lipid 14 LNP RBD-hFc mRNA induced equal cellular and humoral responses in mice at an mRNA dose of 5 μg, only lipid 14 LNP RBD-hFc mRNA exhibited strong immunogenicity following intradermal administration. Both intradermal administration and intramuscular administration of lipid 14 LNPs could activate antigen presenting cells (APCs), thus inducing cellular responses.
DC82301	IC-8 Featured	IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.
DC82303	SSPalmM Featured	SSPalmM is an ionizable cationic disulfide-cleavable (SS-cleavable) proton-activated lipid-like material (SSPalm).
DC82305	80-O16B Featured	80-O16B is a disulfide bond-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 for genome editing in mice. LNPs containing 80-O16B conjugated to phenylboronic acid (PBA) and encapsulating an mRNA reporter increase luciferase reporter expression in HeLa cancer cells.2 LNPs containing 80-O16B conjugated to PBA and encapsulating p53 mRNA decrease the viability of DU145 prostate and SiHa and HeLa cervical cancer cells.
DC83320	A-066	A066 is a lipid for RNA and vaccine delivery.A-066 is an analog of DODMA that contains a pyrrole head group. A-066 LNPs encapsulating TetR siRNA could induce significant antitumor efficacy in orthotopic hepatocellular carcinoma models.
DC83215	DMAP-BLP	DMAP-BLP is a lipid for RNA and vaccine delivery.DMAP-BLP exhibits optimized bilayer destabilizing and pKa properties leading to highly potent gene silencing in hepatocytes following IV administration that is similar to “gold standard” lipids such as DLinMC3-DMA.
DC60352	DDAB	Dimethyldioctadecylammonium bromide (DDAB) is a cationic surfactant that is used as an antimicrobial agent.
DC60361	DLin-K-DM4
DC60362	DLenDMA Featured	DlenDMA is a lipid for RNA and vaccine delivery. DLenDMA showed better siRNA transfection efficiency than DODMA.
DC60364	GL67	GL 67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL-67 can be used for nucleic acid agents and vaccines delivery, and gene transfection[1]. Genzyme Lipid (GL67), The cationic lipid N4 -cholesteryl-spermine is one of the most effective non-viral gene carriers comprising spermine as a headgroup that bond in a T-shape configuration to a cholesterol anchor.
DC60365	BGTC	BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids.
DC60366	DLinDAP
DC60388	C2-DLinDMA
DC60390	DLin-K-C4-DMA
DC83230	TNT-b10 Featured	TNT-b10 is a novel Lipid-like compound suitable for delivery of siRNA and mRNA both in vitro and in vivo TNT-b10 LLNs was more than 10-fold more potent than TNT-a10 LLNs formulated under the same condition.
DC72701	mono-Pal-MTO	mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer drug mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.
DC72708	di-Pal-MTO	di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer drug mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.
DC83220	ALC-0315 analgous-1 Featured	ALC-0315 analgous-1 is an ethanolamine ionizable lipid with both ester bonds located adjacent to C8 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315.
DC60405	C13-112-tri-tail	C13-112-tri-tail is an ionizable lipid molecule containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. The lipoid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in vivo. This includes siRNA to induce gene silencing in a sequence-specific manner, CAS9 mRNA, and cytotoxic proteins. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC60406	C13-113-tri-tail	C13-113-tri tail is an ionizable lipid molecule containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. The lipoid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in vivo. This includes siRNA to induce gene silencing in a sequence-specific manner, CAS9 mRNA, and cytotoxic proteins. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC60407	C13-112-tetra-tail	C13-112-tetra-tail is an ionizable lipid molecule containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. The lipoid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in vivo.
DC60408	C13-113-tetra-tail	C13-113-tetra tail is an ionizable lipid molecule containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker.
DC60421	DC-6-14	DC-6-14 is a cationic lipid that can be used for drug delivery, gene transfection and vaccine delivery. DC-6-14 may be used for research into in vitro and in vivo nucleic acid and protein delivery. Reagent grade, for research use only.

Cationic/Ionizable Lipids

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