Cationic/Ionizable Lipids

As one of the major supplier in market, DC Chemicals provide more than 500 novel cationic ionizable lipids with wide range of diverse chemical structures for RNA delivery.

Cationic ionizable lipids play a major role in the LNP formulation and its ability to transfect target cells with its cargo. The ionizable lipids are used to complex negatively charged nucleic acid cargo. The mRNA-cationic lipid complex fuses with the cell membrane and is then delivered into the cytosol. To be able to play these roles efficiently, a cationic ionizable lipid must be engineered with a suitable apparent acid dissociation constant (pKa). The apparent pKa of a cationic ionizable lipid is the likely pKa at the LNP surface. Currently, the cationic ionizable lipids in FDA-approved therapeutics all have an apparent pKa between 6-7. This is crucial for the cationic ionizable lipid to maintain a neutral charge while in systemic circulation (pH above the pKa of the lipid, pH ~7.5), as well as its ability to become positively charged in the endosome (pH ~6.5) and facilitate membrane fusion and subsequent cytosolic release.

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Cat. No.	Product Name	Field of Application
DC65357	BP Lipid 109	BP Lipid 109 is an amine lipid which has long (11 carbons) lipid tail on the primary ester. Both esters are located at C7 position and the head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.
DC65358	BP Lipid 110	BP Lipid 110 is an ionizable amino lipid with ester likages located at C6 and C7 position relative to amine. The ethanolamine moiety can enhance encapsulation of mRNA. The lipid has a relatively short primary ester lipid tail (7C). Reagent grade, for research purpose.
DC65359	BP Lipid 111	BP Lipid 111 is an ionizable amine lipid with ethanolamine head for efficient mRNA encapsulation. The lipid has two ester linkages at C6 and C7 position. The C6 ester has a 9-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65360	BP Lipid 112	BP Lipid 112 is an amine lipid with two ester linkages at C6 and C7 position. The C6 ester has a long 11 carbons lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65361	BP Lipid 113	BP Lipid 113 is an ionizable lipid analogous to SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 and C8 position relative to the amine nitrogen. The primary ester at C6 position has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65362	BP Lipid 114	BP Lipid 114 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds are located at C6 and C8 position relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.
DC65363	BP Lipid 116	BP Lipid 116 is an ionizable amine lipid with ethanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated, at C7 adn C6 position relative to amine, in the structure to increase tissue clearance of the lipid in the liver. The primary ester has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65364	BP Lipid 117	BP Lipid 117 is an ethanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 and C6 relative to amine nitrogen, are introduced in the structure to improve tissue clearance. Reagent grade, for research purpose.
DC65365	BP Lipid 118	BP Lipid 118 is an amino ionizable lipid with ester bonds located at C7 and C6 poisiton relative to nitrogen. The ethanolamine head can effectively improve mRNA encapsulation while introduction of ester bonds improve tissue clearance. The primary ester contains a long 11 carbons tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.
DC65366	BP Lipid 119	BP Lipid 119 is an ionizable amino lipid with both ester linkages located at C7 and C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The ethanolamine head help encapsulation of mRNA while the introduction of secondary ester can improve protein expression. Reagent grade, for research purpose.
DC65367	BP Lipid 120	BP Lipid 120 is an amine lipid with two ester linkages at C7 and C8 position relative to the amine. The C7 ester has a medium length (9 carbons) lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65368	BP Lipid 121	Lipid 121 is an amino lipid which has a long (11 carbons) lipid tail on the primary ester located at C7 relative to nitrogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The secondary ester is introduced, on the ester located at C8 position relative to amine, to improve protein expression in the liver. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.
DC65369	BP Lipid 122	BP Lipid 122 is an ionizable amine lipid with ethanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated in the structure at C8 adn C6 position relative to amine. These introduction of ester bonds can increase tissue clearance of the lipid in the liver. The primary ester at C8 poisition has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65370	BP Lipid 123	BP Lipid 123 is an ionizable amino lipid with both ester linkages located at C8 and C6 position relative to nitrogen amine. There is 9 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. The lipid head contains ethanolamine which can effectively encapsulate mRNA for gene therapies. Reagent grade, for research purpose.
DC65371	BP Lipid 124	BP Lipid 124 is an ethanolamine ionizable lipid with 11 carbon of primary-ester lipid tail. The ethanolamine head helps with mRNA encapsulation. The ester bonds are located at C8 and C6 position relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.
DC65372	BP Lipid 125	BP Lipid 125 is an ionizable lipid analogous to SM-102. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 and C7 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65373	BP-26383	BP Lipid 126 is an amino ionizable lipid with ester bonds located at C8 and C7 position relative to nitrogen. The ester linkages are introduced to improve tissue clearance. The ethanolamine head can effectively enhance mRNA encapsulation. The primary ester at C8 position contains 9 carbons lipid tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.
DC65374	BP Lipid 127	BP Lipid 127 is an ethanolamine ionizable lipid with 11 carbons lipid tail attached on the primary-ester located at C8 position relative to amine. The second ester bond is located at C7 position relative to the amine nitrogen and has secondary ester lipid tail which can improve protein expression. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.
DC65375	BP Lipid 210	BP Lipid 210 is an ionizable lipid used to prepare lipid nanoparitlcels (LNPs). The lipid has ethanolamine as a lipid head group which enhances the mRNA encapsulation and provides exceptional physiochemical properties. The esters of the lipid are at the C10 and C8 position relative to the amine. The primary ester has a relatively long lipid tail (9 carbons). The lipid can be used for mRNA delivery. Reagent grade, for research purpose.
DC65376	BP Lipid 209	BP Lipid 209 is an amine lipid which has a 9-carbons lipid tail on the primary ester. Both esters are located at C8 and C10 position relative to the amine nitrogen. The head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.
DC65378	BP Lipid 213	BP Lipid 213 is an amino lipid with ester bonds located at C10 and C8 position relative to nitrogen amine. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.
DC65379	BP Lipid 212	BP Lipid 212 is an amino ionizable lipid analogous to BP-25499. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 and C10 position relative to the amine nitrogen. The primary ester has lipid a long 11-carbons tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65380	BP Lipid 214	BP Lipid 214 is an inonizable amine lipid with two ester linkages at C10 position relative to amine. The primary C10 ester has a long 11 carbons lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65383	BP Lipid 128	BP Lipid 128 is an ionizable lipid analogous to SM-102. The propanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65384	BP Lipid 129	BP Lipid 129 is an amine ionizable lipid used to prepare lipid nanoparitlcels (LNPs). The lipid has propanolamine as a lipid head group which enhances the mRNA encapsulation and provides exceptional physiochemical properties. Both esters of the lipid are at the C6 position relative to the amine. The lipid can be used for mRNA delivery. Reagent grade, for research purpose.
DC65385	BP Lipid 130	BP Lipid 130 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.BP Lipid 130 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65386	BP Lipid 131	BP Lipid 131 is an amino ionizable amine lipid with propanolamine head to enhance mRNA encapsulation. Ester linkages at C7 position relative to amine are introduced into the structure to improve tissue clearance. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65387	BP Lipid 132	BP Lipid 132 is a propanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The propanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 relative to amine nitrogen, improve tissue clearance. Reagent grade, for research purpose.
DC87056	C12-113	C12-113 is a novel polyamine-derived lipidoid for gene delivery.
DC65388	BP Lipid 133	BP Lipid 133 is an amino ionizable lipid with ester bonds located at C7 relative to nitrogen. The propanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

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Cationic/Ionizable Lipids

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