Cationic/Ionizable Lipids

As one of the major supplier in market, DC Chemicals provide more than 500 novel cationic ionizable lipids with wide range of diverse chemical structures for RNA delivery.

Cationic ionizable lipids play a major role in the LNP formulation and its ability to transfect target cells with its cargo. The ionizable lipids are used to complex negatively charged nucleic acid cargo. The mRNA-cationic lipid complex fuses with the cell membrane and is then delivered into the cytosol. To be able to play these roles efficiently, a cationic ionizable lipid must be engineered with a suitable apparent acid dissociation constant (pKa). The apparent pKa of a cationic ionizable lipid is the likely pKa at the LNP surface. Currently, the cationic ionizable lipids in FDA-approved therapeutics all have an apparent pKa between 6-7. This is crucial for the cationic ionizable lipid to maintain a neutral charge while in systemic circulation (pH above the pKa of the lipid, pH ~7.5), as well as its ability to become positively charged in the endosome (pH ~6.5) and facilitate membrane fusion and subsequent cytosolic release.

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Cat. No.	Product Name	Field of Application
DC65389	BP Lipid 134	BP Lipid 134 is an ionizable amino lipid with both ester linkages located at C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. Reagent grade, for research purpose.
DC65390	BP Lipid 135	BP Lipid 135 is an amino ionizable lipid with propanolamine lipid head which can improve mRNA encapsulation. The ester bonds are located at C8 position relative to nitrogen amine. There is 9 carbons chain on the primary ester lipid tail. The lipid can be used for preparation mRNA vesicle in gene therapy. Reagent grade, for research purpose.
DC65391	BP Lipid 136	BP Lipid 136 is an amino lipid which has long (11 carbons) lipid tail on the primary ester. Both esters are located at C7 position and the head contains propanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.
DC65392	BP Lipid 137	BP Lipid 137 is an ionizable amino lipid with ester likages located at C6 and C7 position relative to amine. The propanolamine moiety can enhance encapsulation of mRNA. The lipid has a relatively short primary ester lipid tail (7C). Reagent grade, for research purpose.
DC65393	BP Lipid 138	BP Lipid 138 is an ionizable amine lipid with propanolamine head for efficient mRNA encapsulation. The lipid has two ester linkages at C6 and C7 position. The C6 ester has a 9 carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65394	BP Lipid 139	BP Lipid 139 is an amine lipid with two ester linkages at C6 and C7 position. The C6 ester has a long 11 carbons lipid tail. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65395	BP Lipid 140	BP Lipid 140 is an ionizable lipid analogous to SM-102. The propanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C6 and C8 position relative to the amine nitrogen. The primary ester at C6 position has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65396	BP Lipid 141	BP Lipid 141 is a propanolamine ionizable lipid with ester bonds located at C6 and C8 relative to amine nitrogen. The ester linkages can improve tissue clearance. The ester at C6 position has a 9-carbon lipid tail. The propanolamine head helps with mRNA encapsulation. Reagent grade, for research purpose.
DC65397	BP Lipid 142	BP Lipid 142 is an ionizable amine lipid analogous to SM-102. The propanolamine head improves encapsulation of mRNA. The lipid has both esters at C6 and C8 position relative to the amine nitrogen. Ester linkages in the lipid tails are introduced into the structure to improve tissue clearance. The primary ester located at C6 is attached with a long (11-carbon) lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65398	BP Lipid 143	BP Lipid 143 is an ionizable amino lipid with propanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated, at C7 adn C6 position relative to amine, in the structure to increase tissue clearance of the lipid in the liver. The primary ester has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65399	BP Lipid 144	BP Lipid 144 is a propanolamine ionizable lipid with 9 carbon of primary-ester lipid tail. The propanolamine head helps with mRNA encapsulation. The ester bonds, located at C7 and C6 relative to amine nitrogen, are introduced in the structure to improve tissue clearance. Reagent grade, for research purpose.
DC65400	BP Lipid 145	BP Lipid 145 is an amino ionizable lipid with ester bonds located at C7 and C6 poisiton relative to nitrogen. The propanolamine head can effectively improve mRNA encapsulation while introduction of ester bonds improve tissue clearance. The primary ester contains a long 11 carbons tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.
DC65401	BP Lipid 146	BP Lipid 146 is an ionizable amino lipid with both ester linkages located at C7 and C8 position relative to nitrogen amine. There is 7 carbons chain on the primary ester lipid tail. The propanolamine head help encapsulation of mRNA while the introduction of secondary ester can improve protein expression. Reagent grade, for research purpose.
DC65402	BP Lipid 147	BP Lipid 147 is an amine lipid with two ester linkages at C7 and C8 position relative to the amine. The C7 ester has a medium length (9 carbons) lipid tail. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65403	BP Lipid 148	BP Lipid 148 is an amino lipid which has a long (11 carbons) lipid tail on the primary ester located at C7 relative to nitrogen amine. The head contains propanolamine which can efficiently encapsulate mRNA. The secondary ester is introduced, on the ester located at C8 position relative to amine, to improve protein expression in the liver. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose.
DC65404	BP Lipid 149	BP Lipid 149 is an ionizable amine lipid with propanolamine head which can efficiently encapsulate mRNA. Ester linkages are incorporated in the structure at C8 adn C6 position relative to amine. These introduction of ester bonds can increase tissue clearance of the lipid in the liver. The primary ester at C8 poisition has a 7-carbons lipid tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65405	BP Lipid 150	BP Lipid 150 is an ionizable amino lipid with both ester linkages located at C8 and C6 position relative to nitrogen amine. There is 9 carbons chain on the primary ester lipid tail. The secondary ester is introduced to improve protein expression. The lipid head contains propanolamine which can effectively encapsulate mRNA for gene therapies. Reagent grade, for research purpose.
DC65406	BP Lipid 151	BP Lipid 151 is a propanolamine ionizable lipid with 11 carbon of primary-ester lipid tail. The propanolamine head helps with mRNA encapsulation. The ester bonds are located at C8 and C6 position relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.
DC65407	BP Lipid 152	BP Lipid 152 is an ionizable lipid analogous to SM-102. The propanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 and C7 position relative to the amine nitrogen. The primary lipid tail has 7 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose.
DC65408	BP-26410	BP Lipid 153 is an amino ionizable lipid with ester bonds located at C8 and C7 position relative to nitrogen. The ester linkages are introduced to improve tissue clearance. The propanolamine head can effectively enhance mRNA encapsulation. The primary ester at C8 position contains 9 carbons lipid tail. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.
DC65409	BP Lipid 154	BP Lipid 154 is a propanolamine ionizable lipid with 11 carbons lipid tail attached on the primary-ester located at C8 position relative to amine. The second ester bond is located at C7 position relative to the amine nitrogen and has secondary ester lipid tail which can improve protein expression. The introduction of ester linkages can improve the clearance of the lipid in the liver. Reagent grade, for research purpose.
DC65410	BP Lipid 226	BP Lipid 226 is an amino ionizable lipid analogous to ALC-0315. The ethanolamine lipid head enhances encapsulation of mRNA. The lipid has identical ester bonds located adjacent to C6 relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC65411	BP Lipid 216	BP Lipid 216 is an amine lipid which has both ester bonds located adjacent to C7 relative to the nitogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC65412	Acuitas Lipid III-2 Featured	Acuitas Lipid III-2 is an ionizable amine lipid with two identical ester tails adjacent to C6 position relative to amine from patent:WO2017075531A1 with the similar activity as ALC-0315. The head of lipid is propanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle.
DC65413	BP Lipid 219	BP Lipid 219 is an amine ionizable lipid analogous to BP-25498 (ALC-0315). The propanolamine lipid head enhances encapsulation of mRNA. The lipid has identical ester bonds located adjacent to C7 relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC65414	BP Lipid 220	BP Lipid 220 is an amino lipid which has both ester bonds located adjacent to C8 relative to the nitogen amine. The head contains propanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC65415	BP Lipid 221	BP Lipid 221 is an ionizable amino lipid which has both ester bonds located adjacent to C7 relative to the nitogen amine. This lipid is an analogous to BP-25498/ALC-0315. The head contains butanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC65417	BP Lipid 223	BP Lipid 223 is an pentanolamine lipid with both ester bonds located adjacent to C6 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC65418	BP Lipid 224	BP Lipid 224 is an amino ionizable lipid analogous to BP-25498/ALC-0315. The pentanolamine lipid head enhances encapsulation of mRNA. The lipid has identical ester bonds located adjacent to C7 relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC65420	BP Lipid 313

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Cationic/Ionizable Lipids

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