| DC11105 |
Umibecestat
Featured
|
beta-secretase inhibitor. |
|
| DC7373 |
Betrixaban
Featured
|
Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a). |
|
| DC11389 |
BI 409306
Featured
|
BI 409306 is an inhibitor of phosphodisterase 9A（PDE9A）. |
|
| DC11842 |
BI 135585 |
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively. |
|
| DC10404 |
BIA 10-2474
Featured
|
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions. |
|
| DCAPI1112 |
BIBR 953(Dabigatran)
Featured
|
BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. |
|
| DC1010 |
BIBR-1048 (Dabigatran etexilate)
Featured
|
BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. |
|
| DC11761 |
BMS-816336 |
A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM. |
|
| DC10131 |
BMS-986205(Linrodostat)
Featured
|
BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial |
|
| DC8446 |
BRD7116
Featured
|
BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity. |
|
| DC8089 |
BVT 2733(BVT.2733)
Featured
|
BVT 2733 is a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor,protecting osteoblasts against endogenous glucocorticoid induced dysfunction. |
|
| DC8278 |
BVT-14225
Featured
|
BVT 14225 is a new selective 11b-HSD1 inhibitor, it belongs to a class of arylsulfonamidothiazoles with in vitro and in vivo antidiabetic effects |
|
| DC12041 |
BW-A 78U
Featured
|
BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. |
|
| DC9528 |
C75 (trans)
Featured
|
C75 trans is the trans form of C75; C75 is a potent fatty-acid synthase(FASN) inhibitor with IC50 of 35.4 μM(LNCaP cell Proliferation inhibition).
|
|
| DC7697 |
CA-074-Me
Featured
|
CA-074 Me is a selective and cell-permeable inhibitor of cathepsin B. |
|
| DC8975 |
Captopril |
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). |
|
| DC8705 |
Carbosulfan |
Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4. |
|
| DC9384 |
Carboxypeptidase G2 (CPG2) Inhibitor
Featured
|
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents. |
|
| DCAPI1119 |
Cathepsin Inhibitor 1
Featured
|
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
|
| DC11709 |
CB-1158 |
CB-1158 (INCB-01158) is a potent, selective, oral available Arginase inhibitor with IC50 of 98 nM. |
|
| DC10909 |
BN82002
Featured
|
CDC25 Phosphatase Inhibitor I, BN82002, is a cell-permeable ortho-hydroxybenzylamino compound that has been reported to display antitumor properties. |
|
| DC10433 |
CDD3505 |
CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. |
|
| DC10432 |
CDD3506 |
CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. |
|
| DC8116 |
Tosedostat (CHR2797)
Featured
|
CHR-2797 is an aminopeptidase inhibitor, with IC50 values of 100 nM for LAP3 (LAP), 150 nM for PSAP (PuSA) and 220 nM for CD13 (Aminopeptidase N). |
|
| DC8139 |
GMX1778(CHS-828)
Featured
|
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity. |
|
| DCAPI1569 |
Cilostazol |
Cilastazol is a 2-oxo-quinoline with vasodilator, antimitogenic, antithrombotic, and cardiotonic properties. This compound has been shown to cause inhibition of adenosine uptake, eventually resulting in changes to cAMP levels. Studies have shown Cilostazo |
|
| DC9325 |
Cilazapril (monohydrate)
Featured
|
Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
|
|
| DC9582 |
Cilomilast |
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
|
| DC2046 |
Cobicistat (GS-9350)
Featured
|
Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
|
| DC9385 |
CPA inhibitor |
CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA). |
|
