| DC11518 |
Cavosonstat
Featured
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Cavosonstat is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator. |
|
| DC12016 |
NB 001 |
A potent, relatively selective and orally active adenylyl cyclase 1 (AC1) inhibitor with IC50 of 10 uM (cAMP production inhibition). |
|
| DC12017 |
NKY80 |
A potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively. |
|
| DC11868 |
Freselestat |
A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM. |
|
| DC11897 |
Garvagliptin |
A potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment for type 2 diabetes.. |
|
| DC11857 |
BAY-8040 (R)
Featured
|
Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension. |
|
| DC11630 |
ND-378 |
A potent, selective MMP-2 inhibitor with Ki of 230 nM. |
|
| DC11660 |
PF-4181366 |
A potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM. |
|
| DC11858 |
BAY-678
Featured
|
BAY-678 is a cell-permeable inhibitor of human neutrophil elastase (HNE). |
|
| DC11898 |
Gosogliptin |
A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM. |
|
| DC11899 |
Gosogliptin dihydrochloride |
A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM. |
|
| DC11691 |
NSC95397
Featured
|
A potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively. |
|
| DC12014 |
NSC117079 |
A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2. |
|
| DC12013 |
NSC45586
Featured
|
A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2. |
|
| DCAPI1468 |
Rosuvastatin Calcium
Featured
|
A selective, competitive inhibitor of HMG-CoA reductase, that is also antilipemic. |
|
| DC11884 |
Sercloremine hydrochloride |
A selective, reversible inhibitor of MAO-A and serotonin reuptake inhibitor as an antidepressant.. |
|
| DC11885 |
Sercloremine |
A selective, reversible inhibitor of MAO-A and serotonin reuptake inhibitor as an antidepressant.. |
|
| DC11638 |
BCI(NSC 150117)
Featured
|
BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish. |
|
| DC11304 |
A939572
Featured
|
A939572 is a potent, and orally bioavailable SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. |
|
| DC2710 |
Abiraterone (CB-7598) |
Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM. |
|
| DC11155 |
ABX-1431
Featured
|
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
|
| DC11183 |
ABX-1431 hydrochloride
Featured
|
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
|
| DC8798 |
Acotiamide
Featured
|
Acotiamide acts as an acetylcholinesterase inhibitor |
|
| DC8051 |
AG-120 (Ivosidenib)
Featured
|
AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein. |
|
| DC8374 |
AG-221(Enasidenib)
Featured
|
AG-221 is an orally available, selective, potent inhibitor of the mutated IDH2 protein. |
|
| DC10439 |
Vorasidenib (AG881)
Featured
|
AG-881 is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1) in the cytoplasm and type 2 (IDH2). |
|
| DC5050 |
AGI-5198
Featured
|
AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. |
|
| DC7174 |
AGI-6780
Featured
|
AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM). |
|
| DC8723 |
Alda-1
Featured
|
Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). |
|
| DC11024 |
ALDH3A1 inhibitor EN40 |
ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM. |
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