Cat. No. | Product name | CAS No. |
DC8021 |
Indoximod (NLG-8189)
Featured
NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2) |
110117-83-4 |
DC9579 |
Nortadalafil
Featured
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension. IC50 value: Ta |
171596-36-4 |
DC9999 |
NQ301
Featured
NQ301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. |
130089-98-4 |
DC7787 |
NS-2028
NS 2028 is a specific inhibitor of soluble guanylyl cyclase. |
204326-43-2 |
DC7215 |
NSC 405020
Featured
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. |
7497-07-6 |
DC6401 |
Odanacatib (MK 0822)
Featured
Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively. |
603139-19-1 |
DC9583 |
Oglemilast
Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma. |
778576-62-8 |
DC9577 |
Olprinone (Hydrochloride)
Featured
Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. |
119615-63-3 |
DC12281 |
Olutasidenib (FT-2102)
Featured
Olutasidenib is a highly potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 that could be used in the treatment of acute myeloid leukemia. |
1887014-12-1 |
DC10324 |
Omapatrilat
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively. |
167305-00-2 |
DC9443 |
Otamixaban
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. |
193153-04-7 |
DC10345 |
PDE1-IN-2
PDE1-IN-2 is an inhibitor of PDE1 extracted from patent WO2016/55618 A1, example 31; has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. |
1904611-63-7 |
DC11367 |
PF-04447943
Featured
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
1082744-20-4 |
DC7227 |
PF-04620110
Featured
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
1109276-89-2 |
DC10418 |
PF-04957325
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50 values of 0.7 nM for PDE8A and less than 0.3 nM for PDE8B. |
1305115-80-3 |
DC10050 |
PF05175157
Featured
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. |
1301214-47-0 |
DC11937 |
PF 05180999
Featured
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
1394033-54-5 |
DC10022 |
PF06840003
Featured
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities. |
198474-05-4 |
DC7201 |
PF-2545920(MP-10)
Featured
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
898562-94-2 |
DC7247 |
PF-8380
Featured
PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM. |
1144035-53-9 |
DC7574 |
FIPI
Featured
Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). |
939055-18-2 |
DC11526 |
Praliciguat
Featured
Praliciguat (IW-1973, IW1973) is a potent, orally available sGC stimulator that concentration-dependently increases the production of cGMP with EC50 of 267 nM. |
1628730-49-3 |