| DC23593 |
Imagabalin |
Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2. |
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| DC23565 |
Imagabalin hydrochloride |
Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2. |
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| DC4181 |
Imatinib mesylate
Featured
|
Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
|
| DC8678 |
Imazapic |
Imazapic is a selective herbicide for both the preand post-emergent control of some annual and perennial grasses and some broadleaf weeds |
|
| DC20415 |
Imazaquin |
Imazaquin is an imidazolinone herbicide that effectively controls a broad spectrum of weed species, by inhibiting acetohydroxy acid synthase (AHAS).. |
|
| DC23259 |
IMB-301 |
IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM). |
|
| DC23731 |
iMDK |
iMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF. |
|
| DC20211 |
Imidazole;1,3-diazole; glyoxaline; 1,3-diazacyclopenta-2,4-diene |
Imidazole is a heterocyclic aromatic organic compound. It can be incorporated into many important biological molecules and acts as a corrosion inhibitor for industrial applications. |
|
| DC20207 |
Imidazole-4(5)-acetic Acid Hydrochloride |
Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors. |
|
| DC21292 |
Imipenem |
Imipenem (MK-0787) is a broad-spectrum, semi-synthetic beta-lactam carbapenem that has broad antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.. |
|
| DC10406 |
Imisopasem manganese |
Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD. |
|
| DC21145 |
IMM-01 |
IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM. |
|
| DC21146 |
IMM-02 |
IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM. |
|
| DC10806 |
IMP-1088 |
IMP-1088 is a novel picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NMT2 |
|
| DC12578 |
IMTPPE
Featured
|
IMTPPE (SID3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells. |
|
| DC8450 |
(R)-Equol |
In contrast to the estrogen receptor (ER) selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively. |
|
| DC10918 |
INCB053914 |
INCB053914 (INCB-053914) is a novel potent, and selective ATP-competitive, pan-PIM kinase inhibitor with IC50 of 0.24/30.0/0.12 nM for PIM1/2/3, respectively. |
|
| DC23397 |
INCB054329 |
INCB054329 is a novel potent, orally bioactive BET inhibitor that inhibits binding of BRD2, BRD3 and BRD4 to an acetylated histone H4 peptide with low nanomolar potency. |
|
| DC20176 |
INCB057643
Featured
|
INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. |
|
| DC26025 |
INCB086550(INCB-086550)
Featured
|
INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. |
|
| DC21497 |
INCB10820 |
INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively. |
|
| DC9389 |
INCB3344 |
INCB3344 is a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor; inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).
|
|
| DC11311 |
Incensole |
Incensole is a diterpene originally isolated from frankincense produced by B. carterii.It inhibits degradation of inhibitor of NF-κB (IκBα) in a concentration-dependent manner in TNF-α-stimulated HeLa cells when used at concentrations ranging from 60 to 1 |
|
| DCAPI1701 |
Indacaterol Maleate |
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36. |
|
| DC8914 |
Indacaterol |
Indacaterol(Onbrez; Arcapta) is an ultra-long-acting β-adrenoceptor agonist. |
|
| DC21246 |
Indimitecan |
Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor.. |
|
| DC8906 |
Indinavir
Featured
|
Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. |
|
| DC20984 |
Indisulam
Featured
|
Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines. |
|
| DC23921 |
Indolactam V |
Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively. |
|
| DC9568 |
Indoprofen |
Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies. |
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