| DC10806 |
IMP-1088 |
IMP-1088 is a novel picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NMT2 |
|
| DC12578 |
IMTPPE
Featured
|
IMTPPE (SID3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells. |
|
| DC8450 |
(R)-Equol |
In contrast to the estrogen receptor (ER) selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively. |
|
| DC10918 |
INCB053914 |
INCB053914 (INCB-053914) is a novel potent, and selective ATP-competitive, pan-PIM kinase inhibitor with IC50 of 0.24/30.0/0.12 nM for PIM1/2/3, respectively. |
|
| DC23397 |
INCB054329 |
INCB054329 is a novel potent, orally bioactive BET inhibitor that inhibits binding of BRD2, BRD3 and BRD4 to an acetylated histone H4 peptide with low nanomolar potency. |
|
| DC20176 |
INCB057643
Featured
|
INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. |
|
| DC26025 |
INCB086550(INCB-086550)
Featured
|
INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. |
|
| DC21497 |
INCB10820 |
INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively. |
|
| DC9389 |
INCB3344 |
INCB3344 is a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor; inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).
|
|
| DC11311 |
Incensole |
Incensole is a diterpene originally isolated from frankincense produced by B. carterii.It inhibits degradation of inhibitor of NF-κB (IκBα) in a concentration-dependent manner in TNF-α-stimulated HeLa cells when used at concentrations ranging from 60 to 1 |
|
| DCAPI1701 |
Indacaterol Maleate |
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36. |
|
| DC8914 |
Indacaterol
Featured
|
Indacaterol is a potent, orally administered ultra-long-acting β2 adrenergic receptor (ADRB2) agonist, widely recognized for its therapeutic potential in respiratory and cardiovascular conditions. By selectively activating ADRB2, indacaterol not only enhances bronchodilation but also exhibits a unique mechanism of action by inhibiting NF-κB activity in a β-arrestin2-dependent manner. This dual functionality helps mitigate lung inflammation, prevent further pulmonary damage, and improve lung function in patients with chronic obstructive pulmonary disease (COPD). Beyond its respiratory applications, indacaterol has also emerged as a valuable tool in cardiovascular disease research, offering insights into its broader therapeutic effects. Its multifaceted pharmacological profile positions indacaterol as a promising candidate for addressing complex disease mechanisms and advancing treatment strategies in both respiratory and cardiovascular fields. |
|
| DC21246 |
Indimitecan |
Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor.. |
|
| DC8906 |
Indinavir
Featured
|
Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. |
|
| DC23921 |
Indolactam V |
Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively. |
|
| DC9568 |
Indoprofen |
Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies. |
|
| DC21138 |
Inflachromene
Featured
|
Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells. |
|
| DC9651 |
Ingenol 3-angelate
Featured
|
Ingenol 3-Angelate is a PKC(protein kinase C)activator; anti-cancer drug and an active ingredient in Euphorbia peplus. |
|
| DC9653 |
Ingenol 5,20-Acetonide |
Ingenol 5,20-Acetonide (CAS 77573-43-4) |
|
| DC9654 |
Ingenol 5,20-Acetonide-3-O-angelate |
Ingenol 5,20-Acetonide-3-O-angelate (CAS 87980-68-5) |
|
| DC9652 |
Ingenol-3,4:5,20-diacetonide |
Ingenol-3,4:5,20-diacetonide (CAS 77573-44-5) |
|
| DC22212 |
RNF5 INHIBITOR INH-02
Featured
|
inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1. |
|
| DC7640 |
INH1 |
INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. |
|
| DC12310 |
INH154 |
INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 200 nM and 120 nM for INH in Hela and MB468 cells. |
|
| DC21704 |
Inh2-B1 |
Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain. |
|
| DC7487 |
Pyroxamide
Featured
|
Inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. |
|
| DC8132 |
TAPI-0 (TNF-α processing inhibitor-0) |
Inhibits TNF-α processing. Also a general matrix metalloprotease and TACE inhibitor. |
|
| DC7171 |
INK-128(Sapanisertib)
Featured
|
INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; >200-fold less potent to class I PI3K isoforms. |
|
| DC7873 |
INK-055 (PI3Kγ inhibitor 1) |
INK055 is a dual PI3Kg/d inhibitor. |
|
| DC23238 |
INO-1001 |
INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP) with IC50 of <50 nM in CHO cells. |
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