Potent and highly selective µ opioid agonist

Novel,orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor

Novel DNA primase inhibitor

Novel DNA primase inhibitor

Novel potentiator of β-lactam activity against Gram positive and Gram negative pathogens

Novel antitubercular and antiparasitic agent, possessing excellent in vitro activity against both L. donovani and Leishmania infantum as well as displaying a better safety profile

Analeptic agent, stimulating central nervous system; Anti-barbiturate-overdose

Highly potent cytotoxic microtubule inhibitor

Selective MAO-B inhibitor

Dual orexin receptor antagonist (OX1R and OX2R antagonist or DORA)

Anthelmintic, for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle

Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects

Agonist of GABAA receptors α15 subunits

Novel antibacterial with activity against the Gram-negative bacteria associated with nosocomial infections

Novel effective and selective inhibitor of E. coli topoisomerase I

Novel 2-aminoethyl diphenylborinate (2-APB) analogue, inducing a profound activation of SOCE in DT40 cells, albeit at low concentrations (10 nM), blocking the melatonin-induced [Ca ] cyt increase and SOCE in P. falciparum.

Novel boron-containing dopa-derivative, acting as a bladder relaxant through non-catecholamine receptors

Novel Dual PROTAC for Simultaneous Degradation of EGFR and PARP

First Potent Small Molecule Ligand for MALAT1

Novel highly selective agonist for the δ-opioid receptor, producing less convulsions than most drugs from this family and having antidepressant-like effects

Novel inhibitor of dipeptidyl peptidase 7 (DPP7)

Novel selective DPP8/9 inhibitor, blocking AML progression in vivo