| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11110 | CTDP-32476 | CTDP-32476 is a potent and selective dopamine transporter (DAT) inhibitor and a competitive inhibitor of cocaine binding to the DAT with Ki of 12 nM. |
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| DC22066 | CTN06 | CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively. |
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| DC23400 | CTPB | CTPB is an anacardic acid derivative, was reported as a selective activator of p300 (KAT3B) HAT activity but not PCAF (KAT2B), which enhanced HAT-dependent transcriptional activation. |
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| DC11217 | SLC25A1 inhibitor CTPI-2 Featured | CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo; disrupts self-renewal and |
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| DC9510 | CTS-1027 | CTS-1027 is a potent small molecule inhibitor of MMPs(IC50=0.4 nM/0.6 nM for MMP2/MMP13); >1,000 fold selectivity over MMP1. |
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| DC20934 | CU239 | CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM. |
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| DC20952 | CU-3 | CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region. |
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| DC7544 | CUDC-101 Featured | CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1. |
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| DC23897 | CUR-61414 | CUR-61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM). |
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| DC23726 | Cuspin-1 | Cuspin-1 is a small molecule upregulator of SMN (Survival of Motor Neuron protein) with EC50 of 18 uM. |
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| DC12291 | CVT-12012 | CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. |
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| DC20936 | CWP-232228 | CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus. |
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| DC11980 | CX 4338 | CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM. |
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| DC24074 | CX-546 Featured | CX546 is an AMPA receptor potentiator and GluR activator, binds specifically to the agonist bound non-desensitized receptor. |
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| DC23632 | CX-614 | CX-614 is a positive allosteric modulator of AMPA receptors, shows neuroprotective effects for treatment of Parkinson's disease and Alzheimer's disease. |
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| DC10203 | CXCR2-IN-1 | CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. |
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| DC23524 | CXCR2-IN-68 | CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors. |
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| DC20349 | CXL017 | CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM. |
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| DC10775 | Fadraciclib (CYC065) Featured | CYC065 is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9) with potential antineoplastic and chemoprotective activities. |
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| DC7325 | CYC116 Featured | CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM. |
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| DC26110 | Cyclapolin 1 | Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases. |
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| DC26115 | Cyclapolin 9 | Cyclapolin 9 is a potent, selective, and ATP-competitive polo-like kinase PLK1 inhibitor with IC50 of 500 nM.. |
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| DC10368 | Cyclo(his-pro) | Cyclo(His-Pro) is a cyclic dipeptide structurally related to tyreotropin-releasing hormone. |
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| DC20657 | Cyclocreatine Phosphate | Cyclocreatine Phosphate (AM 285) is an analog of the creatine kinase CKMT1 substrate creatine and inhibitor of the creatine biosynthesis pathway. |
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| DC20350 | Cyclopamine tartrate | Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM. |
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| DC11214 | Cyclophilin inhibitor C31 | Cyclophilin inhibitor C31 (SMCypI C31) is a small-molecule cyclophilin (CypA) inhibitor (SMCypI) with PPIase inhibition IC50 of 0.1 uM, displays anti-HCV activity (HCV Gt1b replicon EC50=0.4 uM) and disrupts the CypA-NS5A interaction. |
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| DC20101 | Cyclosporin A-Derivative 1 Free base | Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin. |
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| DC23630 | Cyclothiazide | Cyclothiazide (Doburil) is a positive allosteric modulator of the AMPA and kainate receptors that potentiates AMPA-mediated glutamate currents. |
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| DC20351 | CYD-1-79 | CYD-1-79 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM), potentiates 5-HT-evoked intracellular calcium release in cells stably expressing the human 5-HT2CR but not the 5-HT2AR cells.. |
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| DC23283 | CYD-2-11 | CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM). |
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