| DC7554 |
SGC-CBP30
Featured
|
SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM, respectively. |
|
| DC8049 |
SNG-1153
Featured
|
SNG-1153 is a synthetic modulator of ER-α36 |
|
| DC8096 |
SR1001 |
SR1001 is a high-affinity synthetic ligand of RORα and RORγ; suppresses TH17 cell differentiation and inhibits autoimmunity. |
|
| DC10218 |
SR-12813（GW 485801）
Featured
|
SR-12813 is a pregnane X receptor (PXR) agonist. |
|
| DC10840 |
SR18292
Featured
|
SR-18292 is a PGC-1α inhibitor. SR-18292 reduces blood glucose, strongly increases hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models of T2D. |
|
| DC11046 |
SR2211
Featured
|
SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells. |
|
| DC12048 |
SR9238
Featured
|
SR9238 is a potent and selective LXR inverse agonist. |
|
| DC8279 |
SR9243
Featured
|
SR9243 is a new inhibitor of The nuclear receptor liver-X-receptor (LXR),inducing LXR-corepressor interaction. |
|
| DC8413 |
STF-083010
Featured
|
STF-083010 is a specific IRE1α endonuclease inhibitor. |
|
| DC10436 |
SYP-5
Featured
|
SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. |
|
| DC9601 |
T0070907
Featured
|
T0070907 is a potent and selective PPARγ antagonist with IC50 of 1 nM; displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. |
|
| DC9842 |
T0901317
Featured
|
T0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). |
|
| DC8024 |
T-5224
Featured
|
T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1, attenuates lipopolysaccharide-induced liver injury in mice. |
|
| DC11846 |
TMP778
Featured
|
TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity. |
|
| DC9184 |
Toremifene Citrate
Featured
|
Toremifene Citrate(NK 622; FC 1157a) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. |
|
| DC8903 |
Troglitazone |
Troglitazone(CS-045), PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity. |
|
| DC10737 |
Tropifexor (LJN452)
Featured
|
Tropifexor (LJN452) is a highly potent non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). |
|
| DC11444 |
TT-10
Featured
|
TT-10 is a novel multifaceted fluorinated compound with promising features of CM proliferative, antioxidant, and antiapoptotic activities in vitro. |
|
| DC11245 |
UAB30 |
UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis. |
|
| DC12102 |
UT-155
Featured
|
UT-155 is a selective androgen receptor (AR) antagonist, with a Ki of 267 nM for AR-RBD. |
|
| DC10339 |
Vadadustat
Featured
|
Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia. |
|
| DC5886 |
Verteporfin (Visudyne)
Featured
|
Verteporfin(CL 318952; Visudyne), a benzoporphyrin derivative monoacid ring A, is a photosensitising drug for photodynamic therapy (PDT) activated by low-intensity, nonheat-generating light of 689nm wavelength. |
|
| DC11844 |
VTP-43742 |
VTP-43742 (VTP43742) is a highly potent, selective, oral RORγt inverse agonist for the treatment of autoimmune disorders, including multiple sclerosis and psoriasis.. |
|
| DC10077 |
WAY-200070
Featured
|
WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects. |
|
| DC7040 |
WAY-362450 (XL335; Turofexorate isopropyl)
Featured
|
WAY-362450 (XL335; Turofexorate isopropyl) is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM.WAY-362450 is useful for dyslipidemia. |
|
| DC1034 |
WY14643 (Pirinixic Acid)
Featured
|
WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with ED50 of 1.5 μM. |
|
| DC7735 |
XCT790
Featured
|
XCT-790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα); induces cell death in chemotherapeutic resistant cancer cells. |
|
| DC11131 |
Leelamine hydrochloride |
|
|
| DC8064 |
AI-10-49
Featured
|
AI-10-49 selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1. |
|
| DC7412 |
R(+)-Etomoxir (sodium salt)
Featured
|
A PPARα agonist and an irreversible CPT-1 inhibitor. |
|
