| DC8447 |
KC7F2
Featured
|
KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study. |
|
| DC10654 |
KG-501(Naphthol AS-E phosphate)
Featured
|
KG-501 is a small molecule inhibitor of Aldolase, Histochemical substrate for alkaline phosphatases. |
|
| DC12043 |
KHS-101
Featured
|
KHS101 is a selective inducer of neuronal differentiation; induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). |
|
| DC2076 |
L-165041
Featured
|
L-165041 is a potent PPARδ agonist (Ki = 6 nM). |
|
| DCAPI1501 |
Lasofoxifene tartrate
Featured
|
Lasofoxifene Tartrate is a non-steroidal selective estrogen receptor modulator (SERM). |
|
| DCAPI1437 |
Lexacalcitol |
Lexacalcitol |
|
| DC7633 |
Ligandrol (VK5211, LGD-4033)
Featured
|
Ligandrol (LGD-4033) is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity. |
|
| DCAPI1355 |
Loteprednol etabonate |
Loteprednol etabonate |
|
| DC10755 |
LSZ-102
Featured
|
LSZ102 is a potent, orally bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. |
|
| DC2072 |
LXR623
Featured
|
LXR-623 is a novel Liver X Receptor modulator |
|
| DC10833 |
LY2955303
Featured
|
LY2955303 is a potent and selective RAR-gamma antagonist for the treatment of osteoarthritis pain. |
|
| DC7459 |
LY500307 |
LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2. |
|
| DC12034 |
MA-0204
Featured
|
MA-0204 is a potent, selective PPARδ modulator with good pharmacokinetic properties. |
|
| DC11236 |
MB-07811 (VK-2809)
Featured
|
MB-07811 (VK-2809) is an orally bioavailable, liver-targeted prodrug of MB07344, which is a thyroid hormone receptor-beta agonist (TRβ) agonist, efficiently converted to MB07344 by liver microsomes in vivo. |
|
| DC5069 |
Enzalutamide (MDV3100)
Featured
|
MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
|
| DC9995 |
MGL-3196(Resmetirom)
Featured
|
MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. |
|
| DC10544 |
MKC3946
Featured
|
MKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research. |
|
| DC7683 |
ML-228 |
ML-228 is a hIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. |
|
| DC9682 |
ML-264
Featured
|
ML264 is a novel small molecule inhibitor of Krüppel-like factor 5 (KLF5). |
|
| DC10121 |
ML-329
Featured
|
ML329 is a small molecule inhibitor of the MITF molecular pathway. |
|
| DC10282 |
ML385
Featured
|
ML385 is a novel and specific NRF2 inhibitor. |
|
| DC11047 |
MRL871
Featured
|
MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM; significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM. |
|
| DC10952 |
MYCMI-6(NSC 354961)
Featured
|
MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay. |
|
| DC10606 |
Mycro-3
Featured
|
Mycro 3 is potent and selective for c-Myc in whole cell assays. |
|
| DC9347 |
N-desmethyl Enzalutamide
Featured
|
N-desmethyl Enzalutamide(N-desmethyl MDV3100) is a major metabolite of Enzalutamide, Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.
|
|
| DC11462 |
NH-125
Featured
|
NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria. |
|
| DCAPI1187 |
Nobiletin (Hexamethoxyflavone) |
Nobiletin (Hexamethoxyflavone) |
|
| DC9037 |
Norethindrone |
Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone. |
|
| DC8346 |
O4I-1
Featured
|
O4I1-1 is a Oct3/4 inducer. Increases Oct3/4 mRNA levels in HEK293 cells by 2.5- and 4-fold at 10 μM and 20 μM, respectively. |
|
| DC8345 |
O4I2
Featured
|
O4I2 is a a new class of small molecules suitable for iPSC generation, showed high activity in enforcing Oct3/4 expression. |
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