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Gly-Pro-pNA(chromogenic substrate)

  Cat. No.:  DC11454   Featured
Chemical Structure
103213-34-9
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Field of application
Gly-Pro-pNA is a chromogenic substrate specifically cleaved by dipeptidyl peptidase IV (DPP IV), an enzyme present in circulation. The enzymatic activity can be measured colorimetrically by detecting the release of p-nitroanilide at 405 nm. DPP IV plays a critical role in inactivating two key peptides, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), which are essential for nutrient-stimulated insulin secretion. This substrate is particularly useful for screening DPP IV inhibitors, which are being explored as potential antidiabetic therapeutics.
Cas No.: 103213-34-9
Chemical Name: (2R)-1-(2-Aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide;hydrochloride
Synonyms: L-Prolinamide,glycyl-N-(4-nitrophenyl)-, monohydrochloride (9CI);GLY-PRO P-NITROANILIDE HYDROCHLORIDE;GP-pNA, Chromogenic Substrate;H-Gly-Pro-pNA;H-Gly-Pro-pNA · HCl;1-(2-aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide,hydrochloride;Gly-Pro-pNA HCl,Gly-Pro-p-nitroanilide;Gly-Pro-pNA;H-Gly-Pro-p-nitroanilide;Gly-Pro-pNA (hydrochloride);glycine-proline p-nitroanilide hydrochloride;(2R)-1-(2-Aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide;hydrochloride
SMILES: Cl.NCC(=O)N1[C@H](CCC1)C(=O)NC2=CC=C([N+](=O)[O-])C=C2
Formula: C13H17ClN4O4
M.Wt: 328.7515
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV).Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). This substrate can be used to screen for DPP IV inhibitors, which have emerged as a new class of experimental antidiabetic agents.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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