Cas No.: | 103213-34-9 |
Chemical Name: | (2R)-1-(2-Aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide;hydrochloride |
Synonyms: | L-Prolinamide,glycyl-N-(4-nitrophenyl)-, monohydrochloride (9CI);GLY-PRO P-NITROANILIDE HYDROCHLORIDE;GP-pNA, Chromogenic Substrate;H-Gly-Pro-pNA;H-Gly-Pro-pNA · HCl;1-(2-aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide,hydrochloride;Gly-Pro-pNA HCl,Gly-Pro-p-nitroanilide;Gly-Pro-pNA;H-Gly-Pro-p-nitroanilide;Gly-Pro-pNA (hydrochloride);glycine-proline p-nitroanilide hydrochloride;(2R)-1-(2-Aminoacetyl)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide;hydrochloride |
SMILES: | Cl.NCC(=O)N1[C@H](CCC1)C(=O)NC2=CC=C([N+](=O)[O-])C=C2 |
Formula: | C13H17ClN4O4 |
M.Wt: | 328.7515 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV).Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). This substrate can be used to screen for DPP IV inhibitors, which have emerged as a new class of experimental antidiabetic agents. |