DC20025 |
Nav1.7-IN-3 |
Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration. |
|
DC20472 |
Naxillin
Featured
|
Naxillin is the first non-auxin-like molecule that promotes root branching, activates a subset of auxin-induced transcripts, including AUX/IAA, SAUR and PIN families; induces auxin response in the basal meristem; represents a valuable tool to further decipher the molecular networks involved in lateral root branching. |
|
DC21362 |
NBC19 |
NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.. |
|
DC7209 |
NBI42902 |
NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm). |
|
DC23638 |
NBQX disodium |
NBQX disodium is the water soluble disodium salt of NBQX, which is a potent, selective and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.15 uM. |
|
DC21364 |
NC-001
Featured
|
NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites.. |
|
DC21366 |
NC-043 |
NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association. |
|
DC22316 |
NCC007
Featured
|
NCC007 is a novel CKIα and CKIδ dual inhibitor. NCC007 that showed stronger period effects (0.32 μM for 5 h period lengthening) in a cellbased circadian assay. |
|
DC23377 |
NCD-25 |
NCD-25 is a novel potent, selective LSD1 inhibitor with IC50 of 0.48 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO.. |
|
DC23353 |
NCD-38 |
NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory
activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM). |
|
DC21369 |
NCGC 00067819
Featured
|
NCGC 00067819 is a small molecule compound that potentiates CREB signaling with EC50 of 16 nM in the primary screen and 79 nM in the CHO CRE-β-lactamase confirmation assay. |
|
DC23699 |
NCGC00071837 |
NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11. |
|
DC21372 |
NCGC00185684 |
NCGC00185684 (ML154) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor. |
|
DC10476 |
NCGC00244536
Featured
|
NCGC00244536 is a potent KDM4A inhibitor with an IC50 of 10 nM. |
|
DC23741 |
NCT-502 |
NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells. |
|
DC20004 |
NCT-506
Featured
|
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM. |
|
DC21387 |
NCX-4016 |
NCX-4016 (Nitroaspirin. |
|
DC9810 |
ND-646
Featured
|
ND-646(ND646) is a small-molecule allosteric inhibitor of acetyl-CoA carboxylase (ACC). |
|
DC23681 |
ND-654 (ND654) |
ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively. |
|
DC10302 |
N-deacetylated BMS-202 |
N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-l/PD-Ll interaction, mainly used for cancer treatment. |
|
DC10438 |
N-Desmethylclozapine
Featured
|
N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor. |
|
DC21374 |
NDT 9513727 |
NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay. |
|
DC12348 |
NE 10790 (3-PEHPC)
Featured
|
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent. |
|
DC12511 |
Nebicapone |
Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM. |
|
DC10551 |
Necrostatin 2 racemate
Featured
|
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. |
|
DC2084 |
Necrostatin-1
Featured
|
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
|
DC23292 |
Necrox-5 methanesulfonate
Featured
|
NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter. |
|
DC21375 |
NecroX-2
Featured
|
NecroX-2 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI. |
|
DCAPI1393 |
Nedaplatin (Aqupla)
Featured
|
Nedaplatin (Aqupla) is a derivative of cisplatin for inhibition of tumor colony forming units with IC50 of 28.5 μg/mL. |
|
DC20473 |
NEDD8 inhibitor M22
Featured
|
NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor. |
|