DC21585 |
Brilaroxazine
Featured
|
RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs. |
|
DC11480 |
Rp-8-bromo-Cyclic AMPS
Featured
|
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. |
|
DC7986 |
RPI-1
Featured
|
RPI-1 is a cell-permeable ATP-competitive tyrosine kinase inhibitor |
|
DC20538 |
Rpn11 inhibitor 35 |
Rpn11 inhibitor 35 is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH. |
|
DC11467 |
RR6
Featured
|
RR6 is a selective, reversible, and competitive vanin inhibitor. |
|
DC22217 |
RRD-251 |
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding. |
|
DC23808 |
RRD-251 hydrochloride |
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding. |
|
DC10036 |
RRx-001
Featured
|
RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. |
|
DC9388 |
RS 504393
Featured
|
RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). |
|
DC20539 |
RSK2-IN-20 |
RSK2-IN-20 is a potent, selective, and durable inhibitpr of RSK2 with IC50 of 47 nM. |
|
DC12486 |
RSV inhibitor compound 1 |
RSV inhibitor compound 1 is a novel potent, orally bioavailable RSV fusion inhibitor with EC50 of 2 nM (RSV Long strain infected HEp-2 cells) without significant cytotoxicity (CC50>100 uM). |
|
DC23097 |
RSV604 R enantiomer |
RSV604 R enantiomer is the R-enantiomer of RSV604, which is a potent respiratory syncytial virus (RSV) inhibitor targeting the nucleocapsid protein, is less active against RSV.. |
|
DC12132 |
RSV-IN-1 |
RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor, with an IC50 of 0.11 μM. |
|
DC21589 |
RTC-30 |
RTC-30 is an orally active, dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 15 uM against H1650 lung adenocarcinoma cells. |
|
DC20540 |
RTC-5 |
RTC-5 is a dual pathway inhibitor of PI3K-AKT and RAS-ERK signaling via putative activation of the tumor suppressor PP2A, exhibits GI50 of 12.6 uM against H1650 lung adenocarcinoma cells. |
|
DC12483 |
RTS-V5
Featured
|
RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3. |
|
DC7985 |
RU 24969 hemisuccinate
Featured
|
RU 24969 hemisuccinate is a potent SR-1A/SR-1B and moderate SR-2C agonist that may also release serotonin. |
|
DC22732 |
RU1968
Featured
|
RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3. |
|
DC23743 |
RU-505 |
RU-505 is an effective inhibitor of the Aβ42-fibrinogen interaction with IC50 of 2.72 uM in FP assays. |
|
DC20803 |
RU-A1 |
RU-A1 is a novel potent BMI1 inhibitor that targets cellular self-renewal in hepatocellular carcinoma (HCC). |
|
DC23090 |
Rubusoside
Featured
|
Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.Rubusoside can improve the survival rate of palmitic acid- induced INS- 1 cells and inhibit the occurrence of apoptosis. |
|
DC7272 |
Rufinamide
Featured
|
Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS). |
|
DC26052 |
Rufloxacin(hydrochloride) |
Rufloxacin is a fluoroquinolone antibiotic. |
|
DC21947 |
Runcaciguat
Featured
|
Runcaciguat is a potent soluble guanylyl cyclase (sGC) stimulator/activator.. |
|
DC20647 |
Rupintrivir
Featured
|
Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM. |
|
DC12093 |
Rutin hydrate (Rutoside hydrate; Quercetin 3-O-rutinoside hydrate) |
Rutin hydrate is a flavonol glycoside, able to cross the blood-brain barrier, and acts by inhibiting JNK and ERK1/2 activation and activating mTOR signalling. |
|
DC21595 |
RV1088 |
RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM. |
|
DC21596 |
RV-1729 |
RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα. |
|
DC21594 |
RV521 |
RV521 is a potent, orally active, small-molecule inhibitor of RSV fusion, demonstrates potent antiviral activity across multiple strains of RSV in vitro.. |
|
DC23389 |
RVX2135 |
RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively. |
|