DC23208 |
SDZ 220-581 ammonium salt |
SDZ 220-581 is a potent, competitive NMDA receptor antagonist with pKi of 7.7, fully protects against maximal electroshock seizures (MES) at oral doses of 10 mg/kg in rats and in mice. . |
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DC9870 |
SDZ285428
Featured
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SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h). |
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DC7031 |
SEA-0400
Featured
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SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger inhibitor with IC50 of 5-33 nM (inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia). |
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DC8424 |
SecinH3 |
SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively. |
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DCAPI1154 |
Secnidazole (Flagentyl) |
Secnidazole (Flagentyl) |
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DC22820 |
Seco Rapamycin sodium salt |
Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin that does not affect mTOR.. |
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DC23052 |
Securinine
Featured
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Securinine is an alkaloid originally isolated from S. suffructicosa.It reduces proliferation of SW480 colon adenocarcinoma cells in a dose- and time-dependent manner via increased Beclin 1 expression and induction of autophagy. |
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DC21633 |
SEL120-34A |
SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively. |
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DC21634 |
SEL120-34A hydrochloride |
SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively. |
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DC21661 |
SEL-201
Featured
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SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively. |
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DC21635 |
SEL24-B489 |
SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively. |
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DC21636 |
SEL24-B489 hydrochloride |
SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively. |
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DC20224 |
Seladelpar sodium salt
Featured
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Seladelpar sodium salt (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM, showing more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. |
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DC8114 |
Selamectin
Featured
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Selamectin is an avermectin derivative prepared by hydrolysis and oximation of doramectin. |
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DC26028 |
RO-3
Featured
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RO-3 is a potent, CNS-penetrant, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1,2,4,5,7)[1]. |
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DC7288 |
SB-657510
Featured
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Selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile act |
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DC21948 |
Selgantolimod |
Selgantolimod is a novel toll-like receptor TLR8 modulator for the treatment of HIV infection.. |
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DC20770 |
Selurampanel |
Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM. |
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DC20914 |
Semapimod |
Semapimod (CNI 1493. |
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DC20915 |
Semapimod hydrochloride |
Semapimod (CNI 1493. |
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DC10687 |
Sematilide hydrochloride
Featured
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Sematilide, also known as CK-1752, is a class III antiarrhythmic. |
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DC20544 |
SEMBL
Featured
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SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65. |
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DC21578 |
Sembragiline |
Sembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM, >600-fold selectivity over MAO-A. |
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DC23735 |
SEN 1269 |
SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM. |
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DC20240 |
SEN-177
Featured
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SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell. |
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DC23129 |
Senexin B
Featured
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Senexin B (SNX2-1-165) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM. |
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DC20545 |
Senktide |
Senktide is a potent, selective agonist of neuromedin K3 (NK3) receptor (EC50 =0.5-3 nM), less potently agonizes the NK1 receptor (EC50=35 µM) and is without effect on the NK2 receptor.. |
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DC23045 |
Senkyunolide A
Featured
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Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. |
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DC23047 |
Senkyunolide I
Featured
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Senkyunolide I may be an active component of L. chuanxiong, traditionally used to treat migraine, it can protect rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3, the neuroprotectiv |
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DC21409 |
Sephin 1
Featured
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Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex. |
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