DC22722 |
T5342126 |
T5342126 is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM. |
|
DC12534 |
T5910047
Featured
|
T5910047 (T-5910047) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM. |
|
DC12533 |
T6167923 |
T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation. |
|
DC22299 |
Tabersonine
Featured
|
Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus. |
|
DC10756 |
PF-06291826(Tafamidis)
Featured
|
Tafamidis is a novel specific transthyretin (TTR) stabilizer or dissociation inhibitor. |
|
DC12377 |
Tafamidis meglumine
Featured
|
Tafamidis is a novel specific transthyretin (TTR) stabilizer or dissociation inhibitor. |
|
DC21609 |
Tafenoquine
Featured
|
Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.. |
|
DC21610 |
Tafenoquine succinate
Featured
|
Tafenoquine succinate (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.. |
|
DC21725 |
TAI-95 |
TAI-95 (TAI 95) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines). |
|
DC7822 |
TAK1 inhibitor(compound 13a) |
TAK 1 inhibitor |
|
DC21729 |
TAK-100 |
TAK-100 is a potent, selective and orally active inhibitor of DPP-4 with IC50 of 5.3 nM, shows no inhibition on DPP2/8/9.. |
|
DC20563 |
TAK1-IN-1 |
TAK1-IN-1 is a potent, selective, Type I (ATP-competitive, DFG-in) TAK1 inhibitor with Kd of 59 nM, a thienopyrimidine scaffold that serves as a good starting point for medicinal chemistry.. |
|
DC7923 |
TAK-599 (ceftaroline fosamil)
Featured
|
TAK-599 is a highly promising parenteral cephalosporin targeted for MRSA infection. |
|
DC21280 |
TAK-659 free base(Mivavotinib)
Featured
|
TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM. |
|
DC8880 |
Orteronel (TAK-700) |
TAK-700 shows potent inhibitory activity against rat, monkey, and human steroid 17,20-lyase inhibitor with IC50 of 54 nM, 27 nM, and 38 nM, respectively. |
|
DC20048 |
TAK-828F |
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM). TAK-828F shows excellent ROR isoforms selectivity (>5000-fold selectivity aga |
|
DC21653 |
Simurosertib (TAK-931)
Featured
|
TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM. |
|
DC7309 |
TAK-960
Featured
|
TAK-960 is a novel, potent and selective Polo-like kinase 1 (PLK1) inhibitor. |
|
DC23153 |
Talabostat |
Talabostat (PT-100, Val-boroPro) is a potent, nonselective, orally available inhibitor of post-proline cleaving serine proteases with Ki of 0.18 nM for DPP4, also potently inhibits DPP8/9 (IC50=1.5/0.76 nM), FAP, DPP2 and some other DASH family enzymes. |
|
DC7310 |
Tamibarotene(Am-80)
Featured
|
Tamibarotene(Am-80) is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. |
|
DC23853 |
TAM-IN-1 |
TAM-IN-1 is a highly potent, macrocyclic inhibitor of Mer and Axl with Ki of <50 pM and 130 pM, respectively.. |
|
DC21957 |
Taminadenant |
Taminadenant is an adenosine receptor A2a antagonist.. |
|
DC9096 |
Tamoxifen
Featured
|
Tamoxifen(ICI-46474) is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. |
|
DC9145 |
Tamsulosin hydrochloride |
Tamsulosin hydrochloride((R)-(-)-YM12617;LY253351) is a selective α1 receptor antagonist. |
|
DC23076 |
Tanshinone I
Featured
|
Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM). |
|
DC23815 |
TAO Kinase inhibitor 1
Featured
|
TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively; increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models. |
|
DC23809 |
TAOK inhibitor 63 |
TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively. |
|
DC21732 |
TAP-311 |
TAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM. |
|
DC7560 |
TAPI-1 |
TAPI-1 is a specific TACE(TNF-α-converting enzyme) inhibitor. |
|
DC7207 |
Tarafenacin(SVT-40776) |
Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. |
|