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Cat. No.	Product Name	Field of Application
DC22681	E 6130	A potent, selective, orally available CX3C chemokine receptor 1 (CX3CR1) modulator that inhibits the fractalkine-induced chemotaxis of human peripheral blood NK cells with IC50 of 4.9 nM.
DC23581	TASP0315003	A potent, selective, orally available GlyT1 inhibitor with IC50 of 1.6 nM, weakly inhibits rat GlyT2 (IC50=138 nM).
DC23611	DCCCyB	A potent, selective, orally available GlyT1 inhibitor with IC50 of 29 nM, demonstrates excellent in vivo occupancy of GlyT1 transporters in vivo..
DC23599	PF-0346275 Featured	PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).
DC23486	DS-1558	A potent, selective, orally available GPR40 agonist with EC50 of 3.7 nM.
DC23300	T-3256336	A potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively.
DC24182	Nilotinib monohydrochloride monohydrate Featured	A potent, selective, orally available inhibitor of both native and mutant Bcr-Abl with IC50 of 20-80 nM.
DC23925	Vaniprevir	A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.
DC23358	CD 161	A potent, selective, orally bioavailable BET bromodomain inhibitor with IC50 of 7.2 and 28.2 nM for BRD4 BD2 and BRD4 BD1, respectively.
DC21177	JNJ 39758979 Featured	JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity.
DC24048	NVP-BKM120 hydrochloride Featured	A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.
DC22882	KRH-3955	A potent, selective, orally bioavailable inhibitor of CXCR4 that efficiently inhibits SDF-1α binding to CXCR4 with IC50 of 0.61 nM.
DC24065	EPZ-011989 trifluoroacetate	A potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
DC23552	AS-2444697 HCl Featured	A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1.
DC22941	AZD-9056	A potent, selective, orally bioavailable P2X7 receptor antagonist.
DC21607	SB-649868 Featured	SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
DC21598	RWJ-56110	A potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.
DC20691	ASP 3652	A potent, selective, peripherally active and orally available FAAH inhibitor for treatment of chronic prostatitis/chronic pelvic pain syndrome..
DC23043	Tpl2-IN-2p	A potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase with IC50 of 50 nM.
DC23933	MK-0893	A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM).
DC20412	II-B08	A potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.
DC11875	GlpG inhibitor 11	A potent, selective, reversible rhomboid proteases inhibitor with Ki of 45 nM for GlpG .
DC22892	KNT-127	A potent, selectove δ-opioid receptor agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively.
DC22563	TN1	A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM.
DC20606	8-Thioquinoline	A potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 2.5 uM..
DC21321	ML349 Featured	A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family.
DC22529	FPTQ	A potent, specific and allosteric mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1, respectively..
DC25075	Sivelestat sodium	A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.
DC23074	Sivelestat Featured	A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.
DC23494	GRI 977143 Featured	A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM).

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