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QX 314 chloride

  Cat. No.:  DC26095   Featured
Chemical Structure
5369-03-9
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More than 5000 active chemicals with high quality for research!
Field of application
A membrane-impermeable sodium channel blocker, blocks sodium current in voltage-clamped nociceptive DRG neurons.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 5369-03-9
Chemical Name: Ethanaminium,2-[(2,6-dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-, chloride (1:1)
SMILES: [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C
Formula: C16H27N2O+.Cl-
M.Wt: 298.85138
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].
Target: sodium channel[1]
In Vitro: QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2]. QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2]. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].
References: [1]. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34. [2]. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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