| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22354 | O-Desmorpholinopropyl Gefitinib | A metabolite of Gefitinib, which is a potent inhibitor of tyrosine phosporylation in EGFR.. |
|
| DC22914 | ST-4206 | A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.. |
|
| DC22824 | Endoxifen hydrochloride | A metabolite of tamoxifen, orally active non-steroidal selective estrogen receptor modulator (SERM) for the treatment of estrogen receptor-positive breast cancer.. |
|
| DC23973 | F16 Featured | A mitochondriotoxic small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. |
|
| DC23225 | Dronedarone | A multichannel blocker agent that has antiarrhythmic activity. |
|
| DC21008 | Fumonisin B1 | A mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS). |
|
| DC23641 | AMG 747 | A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia. |
|
| DC24167 | Bergaptol | A natural furanocoumarin that is found to be a potent inhibitor of debenzylation activity of CYP3A4 enzyme with IC50 of 24.92 uM. |
|
| DC20476 | N-palmitoyl-l-leucine | A natural poduct that functions as a splicing inhibitor with IC50 of 35 uM, blocks a late stage of spliceosome assembly.. |
|
| DC22465 | Gedunin | A natural tetranortriterpenoid compound that inhibits Hsp90 and induce the degradation of Hsp90-dependent client proteins. |
|
| DC25051 | Deoxygedunin | A naturally occurring tetranortriterpenoid that has been found to act as a potent, selective, small-molecule agonist of TrkB with Kd of 1.4 uM. |
|
| DC21030 | FzM1 | A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism. |
|
| DC25093 | Neuromedin N Featured | A neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.. |
|
| DC22366 | Bethoxazin | A new broad spectrum industrial microbicide with applications in material and coating preservation. . |
|
| DC23771 | HuR inhibitor 5 | A newly identified, small molecule HuR inhibitor that disrupts HuR multimerization modules and reduces tumor cell survival and proliferation.. |
|
| DC21556 | RA 839 | A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling. |
|
| DC25046 | OSU-2S | A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively. |
|
| DC23907 | Polyoxyethylene 40 stearate Featured | A non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity. |
|
| DC22395 | NSAH | A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM. |
|
| DC22911 | AH-3960 Featured | A non-peptide small molecule agonist of the PTH1 receptor, activates both the cAMP and calcium signaling pathways.. |
|
| DC21236 | LLL-12 | A nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer. |
|
| DC24049 | Anamorelin fumarate Featured | A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects. |
|
| DC24050 | Anamorelin hydrochloride Featured | A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects. |
|
| DC11662 | CCG-4986 | A non-peptide, selective RGS4 inhibitor that inhibits RGS4/Gα(o) binding with 3 to 5 uM potency. |
|
| DC22428 | Ro 64-6198 hydrochloride | A nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41. |
|
| DC23006 | XIB-4035 | A nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1). |
|
| DC22611 | N6-[2-(4-Aminophenyl)ethyl]adenosine | A non-selective agonist of Adenosine A3 receptor. |
|
| DC22619 | Rotigotine Featured | A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM). |
|
| DC22609 | rac-Rotigotine hydrochloride | A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM). |
|
| DC22662 | Carteolol | A non-selective beta blocker used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.. |
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